Evidence map›Paper›PMID 23038645›Full record

ReviewMovement disorders : official journal of the Movement Disorder Society2012

The neurobiology and neural circuitry of cognitive changes in Parkinson's disease revealed by functional neuroimaging.

Nicola J Ray, Antonio P Strafella

Abstract readReview
In one paragraph

Review in Movement disorders : official journal of the Movement Disorder Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Neurocognitive profile of patients with X-linked dystonia-parkinsonism.Journal of neural transmission (Vienna, Austria : 1996) · 2021
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Effects of levodopa on regional cerebral metabolism and blood flow.Movement disorders : official journal of the Movement Disorder Society · 2015
    Review
  18. How does the bilingual experience sculpt the brain?Nature reviews. Neuroscience · 2014
    Review
  19. The neurobiological basis of cognitive impairment in Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2014
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Nicola J RayMorton and Gloria Shulman Movement Disorder Unit & EJ Safra Parkinson Disease Program, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Antonio P Strafella
Centre for Addiction and Mental Health · CAUniversity of Toronto · CA

Funding

CIHR 110962-1CIHR MOP 110962
6 · The paper itself

Abstract

Patients with Parkinson's disease (PD) often develop a spectrum of cognitive symptoms that can evolve into dementia. Dopamine (DA) replacement medications, though improving motor symptoms, can exert both positive and negative effects on cognitive ability, depending on the severity of the disease and the specific skill being tested. By considering the behavioral and clinical aspects of disease- and treatment-mediated changes in cognition alongside the pathophysiology of PD, an understanding of the factors that govern the heterogeneous expression of cognitive impairment in PD is beginning to emerge. Here, we review the neuroimaging studies revealing the neural correlates of cognitive changes after DA loss and DA replacement as well as those that may accompany the conversion from milder stages of cognitive impairment to frank dementia.

Indexed as

NeurobiologyAnimalsBrainCognition DisordersHumansNerve NetNeuroimagingParkinson Disease

Identifiers

PMID23038645
PMCPMC4452226
OpenAlexW2034665418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.