ArticleOptics express2012
A digital x-ray tomosynthesis coupled near infrared spectral tomography system for dual-modality breast imaging.
Article in Optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Development of digital breast tomosynthesis and diffuse optical tomography fusion imaging for breast cancer detection.Scientific reports · 2020Trial
- Widefield ultra-high-density optical breast tomography system supplementing x-ray mammography.Scientific reports · 2025Article
- Compact breast shape acquisition system for improving diffuse optical tomography image reconstructions.Biomedical optics express · 2023Article
- Performance assessment of MRI guided continuous wave near-infrared spectral tomography for breast imaging.Biomedical optics express · 2021Article
- A review of optical breast imaging: Multi-modality systems for breast cancer diagnosis.European journal of radiology · 2020Review
- Optimal breast cancer diagnostic strategy using combined ultrasound and diffuse optical tomography.Biomedical optics express · 2020Article
- Current and future trends in photoacoustic breast imaging.Photoacoustics · 2019Review
- Improving DOT reconstruction with a Born iterative method and US-guided sparse regularization.Biomedical optics express · 2019Article
- Hybrid time-domain and continuous-wave diffuse optical tomography instrument with concurrent, clinical magnetic resonance imaging for breast cancer imaging.Journal of biomedical optics · 2019Article
- Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging.Journal of biomedical optics · 2018Article
- Emerging Breast Imaging Technologies on the Horizon.Seminars in ultrasound, CT, and MR · 2018Article
- Two step imaging reconstruction using truncated pseudoinverse as a preliminary estimate in ultrasound guided diffuse optical tomography.Biomedical optics express · 2017Article
- Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis.Journal of biomedical optics · 2017Article
- Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.Journal of biomedical optics · 2016Article
- Article
- Frequency domain near-infrared multiwavelength imager design using high-speed, direct analog-to-digital conversion.Journal of biomedical optics · 2016Article
- Calibration and optimization of 3D digital breast tomosynthesis guided near infrared spectral tomography.Biomedical optics express · 2015Article
- Digital Breast Tomosynthesis: State of the Art.Radiology · 2015Article
- Light-emitting diode-based multiwavelength diffuse optical tomography system guided by ultrasound.Journal of biomedical optics · 2014Article
- Anthropomorphic breast phantoms with physiological water, lipid, and hemoglobin content for near-infrared spectral tomography.Journal of biomedical optics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
A Near Infrared Spectral Tomography (NIRST) system has been developed and integrated into a commercial Digital Breast Tomosynthesis (DBT) scanner to allow structural and functional imaging of breast in vivo. The NIRST instrument uses an 8-wavelength continuous wave (CW) laser-based scanning source assembly and a 75-element silicon photodiode solid-state detector panel to produce dense spectral and spatial projection data from which spectrally constrained 3D tomographic images of tissue chromophores are produced. Integration of the optical imaging system into the DBT scanner allows direct co-registration of the optical and DBT images, while also facilitating the synergistic use of x-ray contrast as anatomical priors in optical image reconstruction. Currently, the total scan time for a combined NIRST-DBT exam is ~50s with data collection from 8 wavelengths in the optical scan requiring ~42s to complete. The system was tested in breast simulating phantoms constructed using intralipid and blood in an agarose matrix with a 3 cm x 2 cm cylindrical inclusion at 1 cm depth from the surface. Diffuse image reconstruction of total hemoglobin (HbT) concentration resulted in accurate recovery of the lateral size and position of the inclusion to within 6% and 8%, respectively. Use of DBT structural priors in the NIRST reconstruction process improved the quantitative accuracy of the HbT recovery, and led to linear changes in imaged versus actual contrast, underscoring the advantages of dual-modality optical imaging approaches. The quantitative accuracy of the system can be further improved with independent measurements of scattering properties through integration of frequency or time domain data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.