Evidence map›Paper›PMID 23038174›Full record

Trial reportThe ISME journal2013

Gut microbiome composition is linked to whole grain-induced immunological improvements.

Inés Martínez, James M Lattimer, Kelcie L Hubach, Jennifer A Case, Junyi Yang, Casey G Weber, Julie A Louk, Devin J Rose, Gayaneh Kyureghian, Daniel A Peterson and 2 more

2 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The ISME journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 280 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
280citing papers in PubMed, 13 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02236533 nacompletednot on this mapstarted 2014, after this paper: background citation

Healthy Effects of an Innovative Probiotic Pasta

TypeinterventionalSponsorUniversity of ParmaRan2014 to 2015Enrolled40ConditionsOBESITY, INFLAMMATION, DYSLIPIDEMIA, CONSTIPATIONArmswhole grain pasta
NCT02322112 nacompletednot on this mapstarted 2015, after this paper: background citation

The Alberta FYBER (Feed Your Gut Bacteria morE fibeR) Study: Exploring the Significance of Structure-function Relationships Between Dietary Fiber and the Gut Microbiota in Human Health.

TypeinterventionalSponsorUniversity of AlbertaRan2015 to 2020Enrolled195ConditionsOverweight and ObesityArmsMicrocrystalline Cellulose Supplementation, Acacia Gum Supplementation, Resistant Starch Type 4 Supplementation
3 · Its place in the literature

Who cites it

280 citing papers in PubMed, 13 syntheses or guidelines pooled it, 619 citations in OpenAlex.

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  7. Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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220 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Inés MartínezDepartment of Food Science and Technology, University of Nebraska, Lincoln, NE 68583, USA.
James M Lattimer
Kelcie L Hubach
Jennifer A Case
Junyi Yang
Casey G Weber
Julie A Louk
Devin J Rose
Gayaneh Kyureghian
Daniel A Peterson
Mark D Haub
Jens Walter
Kansas State University · USUniversity of Nebraska–Lincoln · USJohns Hopkins University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.

Indexed as

DietEdible GrainMetagenomeAdultBacteroidetesBifidobacteriumBiodiversityBiomarkersBlood GlucoseCross-Over StudiesEubacteriumFecesFemaleGastrointestinal TractHordeumHumansBiomarkersBlood GlucoseInsulinInterleukin-6

Identifiers

PMID23038174
PMCPMC3554403
OpenAlexW2063686053

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.