ArticlePediatric research2012
Moderate tidal volumes and oxygen exposure during initiation of ventilation in preterm fetal sheep.
Article in Pediatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Surfactant instillation in spontaneously breathing preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2016Pooled it
- Respiratory metrics of neonatal positive pressure ventilation on different ventilatory rates: A simulation study.Resuscitation plus · 2025Article
- Preterm lung and brain responses to mechanical ventilation and corticosteroids.Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- An Innovative Model of Bronchopulmonary Dysplasia in Premature Infants.Frontiers in pediatrics · 2020Article
- Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung.Frontiers in pediatrics · 2019Article
- Effects of budesonide and surfactant in preterm fetal sheep.American journal of physiology. Lung cellular and molecular physiology · 2018Article
- Article
- Maternal and fetal arterial blood gas data in normotensive, singleton, isoflurane anesthetized sheep at 124-126 days of gestation.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017Article
- Article
- [Methods for establishing animal model of bronchopulmonary dysplasia and their evaluation].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Review
- Brief mechanical ventilation causes differential epithelial repair along the airways of fetal, preterm lambs.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Selection of Reference Genes for Gene Expression Studies related to lung injury in a preterm lamb model.Scientific reports · 2016Article
- Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs.PloS one · 2016Article
- Manual Ventilation and Sustained Lung Inflation in an Experimental Model: Influence of Equipment Type and Operator's Training.PloS one · 2016Article
- Animal Models, Learning Lessons to Prevent and Treat Neonatal Chronic Lung Disease.Frontiers in medicine · 2015Review
- Unraveling the Links Between the Initiation of Ventilation and Brain Injury in Preterm Infants.Frontiers in pediatrics · 2015Review
- High-frequency nasal ventilation for 21 d maintains gas exchange with lower respiratory pressures and promotes alveolarization in preterm lambs.Pediatric research · 2014Article
- Sustained inflation at birth did not alter lung injury from mechanical ventilation in surfactant-treated fetal lambs.PloS one · 2014Article
- Ventilation-induced increases in EGFR ligand mRNA are not altered by intra-amniotic LPS or ureaplasma in preterm lambs.PloS one · 2014Article
- Sustained inflation at birth did not protect preterm fetal sheep from lung injury.American journal of physiology. Lung cellular and molecular physiology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundPreterm infants often receive mechanical ventilation and oxygen at birth. Exposure to large tidal volumes (V(T)s) at birth causes lung inflammation, and oxygen may amplify the injury. We hypothesized that normal V(T) ventilation at birth causes lung injury that is exacerbated by 95% oxygen.
methodsThe head and chest of anesthetized preterm fetal sheep (129 ± 1 d gestation) were surgically exteriorized while maintaining the placental circulation. Fetuses were randomized to four groups with either V(T) ventilation to 6 ml/kg or continuous positive airway pressure of 5 cm H2O, and either 95%O2/5%CO2 or 95%N2/5%CO2. Age-matched fetuses were used as controls. After a 15-min intervention, the fetal lamb was returned to the uterus for 1 h 45 min.
resultsIn ventilated lambs, V(T) was 6.2 ± 0.4 ml/kg at 15 min. Ventilation increased proinflammatory cytokines as compared with controls and lambs on continuous positive airway pressure, with recruitment of primarily monocytes to bronchoalveolar lavage fluid. Early response protein 1 was activated around the bronchioles in V(T)-ventilated animals. The 15-min oxygen exposure did not change inflammatory mediators or other markers of lung and oxidative stress.
conclusionA V(T) of 6-7 ml/kg at birth increased early markers of injury and lung inflammation. Brief exposure to 95% oxygen did not alter lung inflammation.
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Registered trials
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