Evidence map›Paper›PMID 23037017›Full record

ArticleOptics express2012

A fiber optic probe design to measure depth-limited optical properties in-vivo with low-coherence enhanced backscattering (LEBS) spectroscopy.

Nikhil N Mutyal, Andrew Radosevich, Bradley Gould, Jeremy D Rogers, Andrew Gomes, Vladimir Turzhitsky, Vadim Backman

Abstract read
In one paragraph

Article in Optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Rectal Optical Markers for In Vivo Risk Stratification of Premalignant Colorectal Lesions.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nikhil N MutyalDepartment of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
Andrew Radosevich
Bradley Gould
Jeremy D Rogers
Andrew Gomes
Vladimir Turzhitsky
Vadim Backman

Funding

Novel Biophotonics Methodology for Colon Cancer ScreeningR01CA128641 · NCI · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM · 2008 to 2012
$7.3M
Transforming Colorectal Cancer Screening through Multimodal Spectral MarkersR01CA156186 · NCI · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI BACKMAN, VADIM, ROY, HEMANT K. · 2011 to 2015
$2.8M
Mechanisms of Light Scattering in Living TissuesR01EB003682 · NIBIB · NORTHWESTERN UNIVERSITY · PI BACKMAN, VADIM, PRADHAN, PRABHAKAR · 2005 to 2013
$2.2M
NCI NIH HHS R01 CA128641NCI NIH HHS R01CA128641NCI NIH HHS R01 CA156186NCI NIH HHS R01CA156186NIBIB NIH HHS R01 EB003682NIBIB NIH HHS R01EB003682
6 · The paper itself

Abstract

Low-coherence enhanced backscattering (LEBS) spectroscopy is an angular resolved backscattering technique that is sensitive to sub-diffusion light transport length scales in which information about scattering phase function is preserved. Our group has shown the ability to measure the spatial backscattering impulse response function along with depth-selective optical properties in tissue ex-vivo using LEBS. Here we report the design and implementation of a lens-free fiber optic LEBS probe capable of providing depth-limited measurements of the reduced scattering coefficient in-vivo. Experimental measurements combined with Monte Carlo simulation of scattering phantoms consisting of polystyrene microspheres in water are used to validate the performance of the probe. Additionally, depth-limited capabilities are demonstrated using Monte Carlo modeling and experimental measurements from a two-layered phantom.

Indexed as

TransducersComputer-Aided DesignEquipment DesignEquipment Failure AnalysisFiber Optic TechnologyNephelometry and TurbidimetryPhotometrySpectrum Analysis

Identifiers

PMID23037017
PMCPMC3635466

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.