ArticleInvestigative ophthalmology & visual science2012
The diabetic ocular environment facilitates the development of endogenous bacterial endophthalmitis.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 32 citations in OpenAlex.
- Cross-Serotype Protection of a PstS-YidR Fusion mRNA Vaccine Against Systemic Infection and Endogenous Endophthalmitis Caused by HypervirulentPathogens (Basel, Switzerland) · 2026Article
- Article
- Ocular Bacterial Infections: A Ten-Year Survey and Review of Causative Organisms Based on the Oklahoma Experience.Microorganisms · 2023Article
- Sterile endogenous panophthalmitis with uncontrolled diabetes.BMJ case reports · 2022Article
- Microbial Signatures in The Rodent Eyes With Retinal Dysfunction and Diabetic Retinopathy.Investigative ophthalmology & visual science · 2022Article
- HypervirulentLife (Basel, Switzerland) · 2021Review
- The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis.PloS one · 2020Article
- Targets of immunomodulation in bacterial endophthalmitis.Progress in retinal and eye research · 2019Review
- Endogenous Group A Streptococcal Endophthalmitis in a Healthy 42-Year-Old Man: A Case Report.The Permanente journal · 2018Article
- Endophthalmitis.Korean journal of ophthalmology : KJO · 2017Review
- Exogenous Streptococcus pneumoniae Endophthalmitis in Diabetic Rabbits.Scientific reports · 2017Article
- Bilateral choroidal detachment with exudative retinal detachment in a patient with septicaemia.BMJ case reports · 2016Article
- Modeling intraocular bacterial infections.Progress in retinal and eye research · 2016Review
- Bloodstream-To-Eye Infections Are Facilitated by Outer Blood-Retinal Barrier Dysfunction.PloS one · 2016Article
- Blood-Retinal Barrier Compromise and Endogenous Staphylococcus aureus Endophthalmitis.Investigative ophthalmology & visual science · 2015Article
- TLR4 contributes to the host response to Klebsiella intraocular infection.Current eye research · 2014Article
- Klebsiella pneumoniae induces an inflammatory response in an in vitro model of blood-retinal barrier.Infection and immunity · 2014Article
- Muller glia in retinal innate immunity: a perspective on their roles in endophthalmitis.Critical reviews in immunology · 2013Review
- Risk Factors for Post-Open-Globe Injury Endophthalmitis.Journal of vitreoretinal diseasesArticle
- A lack of ongoing diabetes is an important factor in preserving eyes from late or suboptimally treated endogenous endophthalmitis secondary toTaiwan journal of ophthalmologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe tested the hypothesis that changes in the diabetic ocular environment facilitate the development of endogenous bacterial endophthalmitis (EBE).
methodsC57BL/6J mice were rendered diabetic with streptozotocin (STZ) for 1, 3, or 5 months' duration. Diabetic and age-matched nondiabetic mice were tail vein-injected with 10(8) CFU of Klebsiella pneumoniae, a common cause of EBE in diabetics. After either 2 or 4 days postinfection, the EBE incidence was assessed by electroretinography, histology, bacterial counts, and myeloperoxidase ELISAs. Blood-retinal barrier (BRB) permeability in uninfected diabetic mice also was determined.
resultsNo cases of EBE were observed among the 1-month diabetic group. Extending the time from diabetes induction to 3 months resulted in a 23.8% EBE incidence after 2 days, and a 22% incidence after 4 days. The incidence of EBE increased to 27% in the 5-month diabetic group. Infected eyes had an average 8.01 × 10(2) and 6.19 × 10(4) CFU/eye for the 3- and 5-month diabetic groups, respectively. There was no significant difference in BRB permeability between control and 1-month uninfected diabetic mice. However, 3- and 5-month diabetic mice had significantly greater BRB permeability than control mice. These results suggested that increasing the time from STZ diabetes induction to 3 and 5 months resulted in an ocular environment more conducive to the development of EBE.
conclusionsThese results demonstrated a correlation between an increase in BRB permeability and an increase in EBE incidence, supporting the hypothesis that diabetic ocular changes contribute to the development of EBE.
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