ArticleBiomaterials2012
A silk-based scaffold platform with tunable architecture for engineering critically-sized tissue constructs.
Article in Biomaterials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed.
- PCL scaffold with well-defined hierarchical pores effectively controls cell migration and alignment of human mesenchymal stem cells.Scientific reports · 2025Article
- Sheet-based extrusion bioprinting: a new multi-material paradigm providing mid-extrusion micropatterning control for microvascular applications.Biofabrication · 2024Article
- Mechanical strategies to promote vascularization for tissue engineering and regenerative medicine.Burns & trauma · 2024Review
- Concentric-mineralized hybrid silk-based scaffolds for bone tissue engineeringJournal of materials chemistry. B · 2023Article
- Generative design ofChem · 2023Article
- New Challenges and Prospective Applications of Three-Dimensional Bioactive Polymeric Hydrogels in Oral and Craniofacial Tissue Engineering: A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Implantable Biomaterials for Peripheral Nerve Regeneration-Technology Trends and Translational Tribulations.Frontiers in bioengineering and biotechnology · 2022Review
- Elimination of Induced Hypoxic Regions in Depth of 3D Porous Silk Scaffolds by the Introduction of Channel Configuration.BioMed research international · 2022Article
- Three-dimensional-printed polycaprolactone scaffolds with interconnected hollow-pipe structures for enhanced bone regeneration.Regenerative biomaterials · 2022Article
- Functionalized 3D-printed silk-hydroxyapatite scaffolds for enhanced bone regeneration with innervation and vascularization.Biomaterials · 2021Article
- Article
- Translational stem cell therapy: vascularized skin grafts in skin repair and regeneration.Journal of translational medicine · 2021Review
- Rheological characterization, compression, and injection molding of hydroxyapatite-silk fibroin composites.Biomaterials · 2021Article
- Preservation of alveolar ridge height through mechanical memory: A novel dental implant design.Bioactive materials · 2021Article
- Estimating Kinetic Rate Parameters for Enzymatic Degradation of Lyophilized Silk Fibroin Sponges.Frontiers in bioengineering and biotechnology · 2021Article
- 3D biofabrication of vascular networks for tissue regeneration: A report on recent advances.Journal of pharmaceutical analysis · 2018Review
- Avidin Adsorption to Silk Fibroin Films as a Facile Method for Functionalization.Biomacromolecules · 2018Article
- Fabrication of Microchannels and Evaluation of Guided Vascularization in Biomimetic Hydrogels.Tissue engineering and regenerative medicine · 2018Article
- Biomacromolecules as carriers in drug delivery and tissue engineering.Acta pharmaceutica Sinica. B · 2018Review
- 3D Printing of Lotus Root-Like Biomimetic Materials for Cell Delivery and Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In the field of tissue engineering and regenerative medicine there is significant unmet need for critically-sized, fully degradable biomaterial scaffold systems with tunable properties for optimizing tissue formation in vitro and tissue regeneration in vivo. To address this need, we have developed a silk-based scaffold platform that has tunable material properties, including localized and bioactive functionalization, degradation rate, and mechanical properties and that provides arrays of linear hollow channels for delivery of oxygen and nutrients throughout the scaffold bulk. The scaffolds can be assembled with dimensions that range from millimeters to centimeters, addressing the need for a critically-sized platform for tissue formation. We demonstrate that the hollow channel arrays support localized and confluent endothelialization. This new platform offers a unique and versatile tool for engineering 'tailored' scaffolds for a range of tissue engineering and regenerative medicine needs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.