ArticleBiological psychiatry2013
Abnormal temporal lobe white matter as a biomarker for genetic risk of bipolar disorder.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Structural connectivity associated with familial risk for mental illness: A meta-analysis of diffusion tensor imaging studies in relatives of patients with severe mental disorders.Human brain mapping · 2022Pooled it
- White Matter Microstructure in Individuals With and At Risk for Bipolar Disorder: Evidence for an Endophenotype From a Voxel-Based Meta-analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Pooled it
- Replicable association between human cytomegalovirus infection and reduced white matter fractional anisotropy in major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Disrupted Rich Club Organization of Hemispheric White Matter Networks in Bipolar Disorder.Frontiers in neuroinformatics · 2020Article
- White matter - emotion processing activity relationships in youth offspring of bipolar parents.Journal of affective disorders · 2019Article
- Shared and differential cortical functional abnormalities associated with inhibitory control in patients with schizophrenia and bipolar disorder.Scientific reports · 2018Article
- Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder.Molecular psychiatry · 2018Article
- The Abnormality of Topological Asymmetry in Hemispheric Brain Anatomical Networks in Bipolar Disorder.Frontiers in neuroscience · 2018Article
- Hemispheric lateralization abnormalities of the white matter microstructure in patients with schizophrenia and bipolar disorder.Journal of psychiatry & neuroscience : JPN · 2017Article
- White matter volumes in youth offspring of bipolar parents.Journal of affective disorders · 2017Article
- A comprehensive tractography study of patients with bipolar disorder and their unaffected siblings.Human brain mapping · 2016Article
- Age-associated alterations in corpus callosum white matter integrity in bipolar disorder assessed using probabilistic tractography.Bipolar disorders · 2015Article
- Diffusion tensor imaging in first degree relatives of schizophrenia and bipolar disorder patients.Schizophrenia research · 2015Review
- All the world's a (clinical) stage: rethinking bipolar disorder from a longitudinal perspective.Molecular psychiatry · 2015Review
- A Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical Correlates.Current neuropharmacology · 2015Review
- A critical appraisal of neuroimaging studies of bipolar disorder: toward a new conceptualization of underlying neural circuitry and a road map for future research.The American journal of psychiatry · 2014Review
- Multisystem component phenotypes of bipolar disorder for genetic investigations of extended pedigrees.JAMA psychiatry · 2014Article
- Toward understanding the functional relevance of white matter deficits in bipolar disorder.JAMA psychiatry · 2014Article
- Abnormal fatty acid pattern in the superior temporal gyrus distinguishes bipolar disorder from major depression and schizophrenia and resembles multiple sclerosis.Psychiatry research · 2014Article
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7 authors at 4 institutions in 1 country.
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Abstract
backgroundBrain white matter (WM) abnormalities have been hypothesized to play an important role in the neurobiology of bipolar disorder (BD). The nature of these abnormalities is not well-characterized, however, and it is unknown whether they occur after disease onset or represent potential markers of genetic risk.
methodsWe examined WM integrity (assessed via fractional anisotropy [FA]) with diffusion tensor imaging in patients with BD (n=26), unaffected siblings of patients with BD (n=15), and healthy volunteers (n=27) to identify WM biomarkers of genetic risk.
resultsThe FA differed significantly (p<.05; corrected) among the three groups within the right temporal WM. Unaffected siblings had FA values that were intermediate to and significantly different from those of healthy volunteers and patients with BD (healthy control subjects>unaffected siblings>BD). Moreover, FA values in this region correlated negatively and significantly with trait impulsivity in unaffected siblings. Probabilistic tractography indicated that the regional abnormality lies along the inferior fronto-occipital fasciculus, a large intrahemispheric association pathway.
conclusionsOur results suggest that lower WM integrity in the right temporal lobe might be a biomarker for genetic risk of BD. It is conceivable that the attenuated nature of these WM abnormalities present in unaffected siblings allows for some preservation of adaptive emotional regulation, whereas more pronounced alterations observed in patients is related to the marked emotional dysregulation characteristic of BD.
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