Evidence map›Paper›PMID 23036838›Full record

ReviewThe American journal of geriatric pharmacotherapy2012

Adverse effects of analgesics commonly used by older adults with osteoarthritis: focus on non-opioid and opioid analgesics.

Christine K O'Neil, Joseph T Hanlon, Zachary A Marcum

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The American journal of geriatric pharmacotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 10 pooled it
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 10 syntheses or guidelines pooled it, 262 citations in OpenAlex.

  1. Pooled it
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  4. Effectiveness of pharmacological and non-pharmacological therapy on pain intensity and disability in older people with chronic nonspecific low back pain: a systematic review with meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023
    Pooled it
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  9. Opioids for agitation in dementia.The Cochrane database of systematic reviews · 2015
    Pooled it
  10. The Efficacy of Acetominophen for Total Laparoscopic Hysterectomy.JSLS : Journal of the Society of Laparoendoscopic Surgeons
    Pooled it
  11. Trial
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  15. Functional Near-Infrared Spectroscopy to Assess Central Pain Responses in a Nonpharmacologic Treatment Trial of Osteoarthritis.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2020
    Trial
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Christine K O'NeilDepartment of Pharmacy Practice, School of Pharmacy, Duquesne University, Pittsburgh, PA, USA.
Joseph T Hanlon
Zachary A Marcum
University of Pittsburgh · USDuquesne University · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Pitt Integrated Clinical and Geroscience Research Training ProgramT32AG021885 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Aditi U Gurkar · 2003 to 2026
$6.7M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
Intervention to Reduce Dietary Sodium in HemodialysisR01NR010135 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEVICK, MARY A · 2008 to 2011
$2.3M
Enhancing the Detection and Management of Adverse Drug Events in the Nursing HomeR01HS018721 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANDLER, STEVEN MARK · 2010 to 2013
$2.0M
The University of Pittsburgh's Comparative Effectiveness Research Scholars PrograK12HS019461 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPOOR, WISHWA N · 2010 to 2010
$1.9M
Longitudinal Impact of CNS Polypharmacy on Geriatric SyndromesR01AG027017 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2006 to 2012
$801k
Impact of Medicare Part D on Racial Disparities in Diabetes Treatment and OutcomeR01HS017695 · AHRQ · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DONOHUE, JULIE MARIE · 2009 to 2011
$628k
UPITT Program for Pharmaceutical Outcomes Research in AgingK07AG033174 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2009 to 2013
$461k
Racial Disparities in Older Adults: Impact of Medicare Part DR01AG034056 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2009 to 2010
$451k
Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric SyndromesR56AG027017 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HANLON, JOSEPH T · 2010 to 2010
$242k
AHRQ HHS K12 HS019461AHRQ HHS R01 HS017695AHRQ HHS R01 HS018721AHRQ HHS R01HS018721NIA NIH HHS K07 AG033174NIA NIH HHS K07AG033174NIA NIH HHS P30 AG024827NIA NIH HHS P30AG024827NIA NIH HHS R01 AG027017NIA NIH HHS R01 AG028050NIA NIH HHS R01AG028050NIA NIH HHS R01 AG034056NIA NIH HHS R01AG034056NIA NIH HHS R56 AG027017NIA NIH HHS R56AG 027017NIA NIH HHS T32 AG021885NINR NIH HHS R01 NR010135
6 · The paper itself

Abstract

backgroundOsteoarthritis (OA) is the most common cause of disability in older adults, and although analgesic use can be helpful, it can also result in adverse drug events.

objectiveTo review the recent literature to describe potential adverse drug events associated with analgesics commonly used by older adults with OA.

methodsTo identify articles for this review, a systematic search of the English-language literature from January 2001 to June 2012 was conducted using PubMed, MEDLINE, EBSCO, and the Cochrane Database of Systematic Reviews for publications related to the medical management of OA. Search terms used were "analgesics," "acetaminophen," "nonsteroidal anti-inflammatory drugs" (NSAIDs), "opioids," "pharmacokinetics," "pharmacodynamics," and "adverse drug events." The search was restricted to those articles that concerned humans aged ≥65 years. A manual search of the reference lists from identified articles and the authors' article files, book chapters, and recent reviews was conducted to identify additional articles. From these, the authors identified those studies that examined analgesic use in older adults.

resultsThere are limited data to suggest that non-frail elders are more likely than their younger counterparts to develop acetaminophen-induced hepatotoxicity. However, decreased hepatic phase II metabolism in frail elders may result in increased risk of hepatotoxicity. It is now well established that older adults are at higher risk of NSAID-induced gastrointestinal toxicity and renal insufficiency. Insofar as opioids, the data that suggest an increased risk of falls, fractures, or delirium need to be tempered by the potential risk of inadequately treating severe chronic OA-related pain.

conclusionsAcetaminophen is the mainstay frontline analgesic for treating OA-related pain in older adults. NSAIDs should be limited to short-term use only, and for moderate to severe OA-related pain, opioids may be preferable in individuals without substance abuse or dependence issues.

Indexed as

AcetaminophenAgedAge FactorsAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalChemical and Drug Induced Liver InjuryFrail ElderlyHumansOsteoarthritisRisk FactorsAcetaminophenAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-Steroidal

Identifiers

PMID23036838
PMCPMC3529168
OpenAlexW2047333386

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.