Evidence map›Paper›PMID 23036836›Full record

ArticleNucleic acids research2013

Interpreting genomic data via entropic dissection.

Rajeev K Azad, Jing Li

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Investigating genomic structure using changept: A Bayesian segmentation model.Computational and structural biotechnology journal · 2014
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rajeev K AzadDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA. Rajeev.Azad@unt.edu
Jing Li
Case Western Reserve University · US

Funding

Multi-point and multi-locus analysis of genomic association dataR01LM008991 · NLM · CASE WESTERN RESERVE UNIVERSITY · PI LI, JING · 2006 to 2010
$3.1M
Inferring the Roadmap of Bacterial Gene TransferR01GM078092 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAWRENCE, JEFFREY G · 2006 to 2009
$655k
NIGMS NIH HHS R01-GM078092NLM NIH HHS R01-LM008991
6 · The paper itself

Abstract

Since the emergence of high-throughput genome sequencing platforms and more recently the next-generation platforms, the genome databases are growing at an astronomical rate. Tremendous efforts have been invested in recent years in understanding intriguing complexities beneath the vast ocean of genomic data. This is apparent in the spurt of computational methods for interpreting these data in the past few years. Genomic data interpretation is notoriously difficult, partly owing to the inherent heterogeneities appearing at different scales. Methods developed to interpret these data often suffer from their inability to adequately measure the underlying heterogeneities and thus lead to confounding results. Here, we present an information entropy-based approach that unravels the distinctive patterns underlying genomic data efficiently and thus is applicable in addressing a variety of biological problems. We show the robustness and consistency of the proposed methodology in addressing three different biological problems of significance--identification of alien DNAs in bacterial genomes, detection of structural variants in cancer cell lines and alignment-free genome comparison.

Indexed as

Bayes TheoremCell Line, TumorCluster AnalysisDNA Copy Number VariationsEscherichia coliGene Transfer, HorizontalGenome, BacterialGenomicsHumansNeoplasmsSalmonella typhi

Identifiers

PMID23036836
PMCPMC3592408
OpenAlexW1984927247

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.