Evidence map›Paper›PMID 23036745›Full record

ReviewThe Journal of allergy and clinical immunology2012

Warts and all: human papillomavirus in primary immunodeficiencies.

Jennifer W Leiding, Steven M Holland

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 182 citations in OpenAlex.

  1. The efficacy of intralesional vitamin D3 injection in the treatment of cutaneous warts: A clinical therapeutic trial study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Trial
  2. Heterozygous variants in DOCK2 leading to susceptibility to viral illnesses.The Journal of allergy and clinical immunology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. The monogenic landscape of human infectious diseases.The Journal of allergy and clinical immunology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jennifer W LeidingLaboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA. jleiding@health.usf.edu
Steven M Holland
National Institute of Allergy and Infectious Diseases · US

Funding

Intramural NIH HHS Z99 AI999999NIAID NIH HHS Y99 AI999999
6 · The paper itself

Abstract

Infection with human papillomavirus (HPV) is almost universal and eventually asymptomatic, but pathologic infection with HPV is severe, recurrent, and recalcitrant to therapy. It is also an underappreciated manifestation of primary immunodeficiency. Mutations in EVER1, EVER2, GATA2, CXCR4, and dedicator of cytokinesis 8 (DOCK8) are typically associated with extensive HPV infections, whereas several other primary immune defects result in severe HPV much less frequently. We review immunodeficiencies with severe HPV infections and the mechanisms underlying them.

Indexed as

AnimalsGenetic Predisposition to DiseaseGuanine Nucleotide Exchange FactorsHumansImmunologic Deficiency SyndromesMembrane ProteinsPapillomaviridaePapillomavirus InfectionsPolymorphism, GeneticProteinase Inhibitory Proteins, SecretoryReceptors, CXCR4Risk FactorsSerine Peptidase Inhibitor Kazal-Type 5Tumor Virus InfectionsWartsCXCR4 protein, humanDOCK8 protein, humanGuanine Nucleotide Exchange FactorsMembrane ProteinsProteinase Inhibitory Proteins, SecretoryReceptors, CXCR4Serine Peptidase Inhibitor Kazal-Type 5SPINK5 protein, humanTMC6 protein, humanTMC8 protein, human

Identifiers

PMID23036745
PMCPMC3517887
OpenAlexW2020602868

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.