Evidence map›Paper›PMID 23036599›Full record

ReviewExperimental neurology2014

Stem cells and modeling of autism spectrum disorders.

Beatriz C G Freitas, Cleber A Trujillo, Cassiano Carromeu, Marianna Yusupova, Roberto H Herai, Alysson R Muotri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Mental health dished up-the use of iPSC models in neuropsychiatric research.Journal of neural transmission (Vienna, Austria : 1996) · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Beatriz C G FreitasUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
Cleber A TrujilloUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
Cassiano CarromeuUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
Marianna YusupovaUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
Roberto H HeraiUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA.
Alysson R MuotriUniversity of California San Diego, School of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, Department of Cellular & Molecular Medicine, Stem Cell Program, La Jolla, CA 92093, MC 0695, USA. Electronic address: muotri@ucsd.edu.

Funding

Williams Syndrome: The Molecular Genetic CharacterizationP01HD033113 · NICHD · UNIVERSITY OF UTAH · PI BELLUGI, URSULA · 1996 to 2015
$19.4M
Project-002P30NS076411 · NINDS · SCINTILLON INSTITUTE FOR PHOTOBIOLOGY · PI LIPTON, STUART A · 2011 to 2016
$4.5M
Modeling autism with human pluripotent cellsDP2OD006495 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MUOTRI, ALYSSON R. · 2009 to 2009
$2.3M
The Impact of L1retrotransposition in the nervous systemR01MH094753 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MUOTRI, ALYSSON R. · 2011 to 2015
$1.9M
Modeling anorexia nervosa with human pluripotent stem cellsR21MH093954 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DUVVURI, VIKAS, MUOTRI, ALYSSON R. · 2012 to 2013
$418k
NICHD NIH HHS P01 HD033113NIH HHS 1-DP2-OD006495-01NIH HHS DP2 OD006495NIH HHS R01 NH094753-02NIMH NIH HHS 1R21MH093954-01A1NIMH NIH HHS R01 MH094753NIMH NIH HHS R21 MH093954NINDS NIH HHS P30 NS076411PHS HHS P01 NICHD033113
6 · The paper itself

Abstract

Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. Here, we discuss recent advances on the use of stem cells and other models to study ASDs, as well as their limitations, implications and future perspectives.

Indexed as

AnimalsCell- and Tissue-Based TherapyChild Development Disorders, PervasiveDisease Models, AnimalHumansNeuronsRett SyndromeStem CellsAngelman syndromeAnimal modelAutism spectrum disordersFragile X syndromeGenomic editingInduced pluripotent stem cellsRett syndromeStem cellsTimothy syndrome

Identifiers

PMID23036599
PMCPMC3568448

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.