Evidence map›Paper›PMID 23036488›Full record

ArticleCancer letters2013

Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment.

Linhua Jin, Yoko Tabe, Hongbo Lu, Gautam Borthakur, Takashi Miida, Hagop Kantarjian, Michael Andreeff, Marina Konopleva

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Linhua JinDepartment of Clinical Laboratory Medicine, Juntendo University School of Medicine, Tokyo, Japan.
Yoko Tabe
Hongbo Lu
Gautam Borthakur
Takashi Miida
Hagop Kantarjian
Michael Andreeff
Marina Konopleva
The University of Texas MD Anderson Cancer Center · USJuntendo University · JP

Funding

University of Texas M.D. Anderson Cancer SPORE-LeukemiaP50CA100632 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KONOPLEVA, MARINA Y · 2003 to 2023
$43.7M
THE THERAPY OF AMLP01CA055164 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI THOMAS, MATTIE J · 1992 to 2011
$25.3M
Targeting hypoxic microenvironment in Acute Lymphocytic LeukemiaR01CA155056 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI KONOPLEVA, MARINA Y · 2011 to 2015
$1.6M
NCI NIH HHS 1R01CA155056-01NCI NIH HHS 5P01 CA55164-17NCI NIH HHS 5 P50 CA100632-08NCI NIH HHS P01 CA055164NCI NIH HHS P50 CA100632NCI NIH HHS R01 CA155056
6 · The paper itself

Abstract

We investigated the antileukemia effects and molecular mechanisms of apoptosis induction by simultaneous blockade of PI3K and mutant FLT3 in AML cells grown under hypoxia in co-cultures with bone marrow stromal cells. Combined treatment with selective class I PI3K inhibitor GDC-0941 and sorafenib reversed the protective effects of bone marrow stromal cells on FLT3-mutant AML cells in hypoxia, which was associated with downregulation of Pim-1 and Mcl-1 expression levels. These findings suggest that combined inhibition of PI3K and FLT3-ITD may constitute a targeted approach to eradicating chemoresistant AML cells sequestered in hypoxic bone marrow niches.

Indexed as

Phosphoinositide-3 Kinase InhibitorsAntineoplastic AgentsApoptosisBone MarrowCell HypoxiaCellular MicroenvironmentCoculture TechniquesEnzyme Inhibitorsfms-Like Tyrosine Kinase 3HumansIndazolesLeukemia, Myeloid, AcuteMutationMyeloid Cell Leukemia Sequence 1 ProteinNiacinamidePhenylurea Compounds2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidineAntineoplastic AgentsEnzyme InhibitorsFLT3 protein, humanfms-Like Tyrosine Kinase 3IndazolesMyeloid Cell Leukemia Sequence 1 ProteinNiacinamidePhenylurea CompoundsPhosphoinositide-3 Kinase InhibitorsPIM1 protein, humanProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-bcl-2Proto-Oncogene Proteins c-pim-1SorafenibSulfonamides

Identifiers

PMID23036488
PMCPMC3572533
OpenAlexW2119281301

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.