ReviewFrontiers in neuroendocrinology2012
Importance of sex to pain and its amelioration; relevance of spinal estrogens and its membrane receptors.
Review in Frontiers in neuroendocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Activation of G protein gated inwardly rectifying potassium (GIRK) channels in keratinocytes mediates peripheral kappa opioid receptor-mediated antinociception.Neuropharmacology · 2025Article
- Estrogen receptors in pain modulation: cellular signaling.Biology of sex differences · 2021Review
- Downregulation of microRNA‑29c reduces pain after child delivery by activating the oxytocin‑GABA pathway.Molecular medicine reports · 2020Article
- Ovarian Hormone-dependent and Spinal ERK Activation-regulated Nociceptive Hypersensitivity in Female Rats with Acid Injection-induced Chronic Widespread Muscle Pain.Scientific reports · 2019Article
- 17β-Estradiol Attenuates Neuropathic Pain Caused by Spared Nerve Injury by Upregulating CIC-3 in the Dorsal Root Ganglion of Ovariectomized Rats.Frontiers in neuroscience · 2019Article
- Toward an effective peripheral visceral analgesic: responding to the national opioid crisis.American journal of physiology. Gastrointestinal and liver physiology · 2018Review
- Pituitary Hormones and Orofacial Pain.Frontiers in integrative neuroscience · 2018Article
- Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- 17beta-estradiol counteracts neuropathic pain: a behavioural, immunohistochemical, and proteomic investigation on sex-related differences in mice.Scientific reports · 2016Article
- Examining the factor structure of the Clinical Opiate Withdrawal Scale: A secondary data analysis from the National Drug Abuse Treatment Clinical Trials Network (CTN) 0003.Drug and alcohol dependence · 2015Article
- Estrogens Suppress Spinal Endomorphin 2 Release in Female Rats in Phase with the Estrous Cycle.Neuroendocrinology · 2015Article
- Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction.Frontiers in neuroscience · 2015Review
- The neuroanatomy of sexual dimorphism in opioid analgesia.Experimental neurology · 2014Review
- Effects of estradiol on voltage-gated potassium channels in mouse dorsal root ganglion neurons.The Journal of membrane biology · 2014Article
- Activation of estrogen receptor α enhances bradykinin signaling in peripheral sensory neurons of female rats.The Journal of pharmacology and experimental therapeutics · 2014Article
- Sex hormones in the modulation of irritable bowel syndrome.World journal of gastroenterology · 2014Review
- Spinal endomorphin 2 antinociception and the mechanisms that produce it are both sex- and stage of estrus cycle-dependent in rats.The journal of pain · 2013Article
- Sex differences and hormonal modulation of deep tissue pain.Frontiers in neuroendocrinology · 2013Review
- Sex differences in opioid analgesia and addiction: interactions among opioid receptors and estrogen receptors.Molecular pain · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Estrogens have a multitude of effects on opioid systems and are thought to play a key role in sexually dimorphic nociception and opioid antinociception. Heretofore, classical genomic actions of estrogens are largely thought to be responsible for the effects of these steroids on nociception and opioid antinociception. The recent discovery that estrogens can also activate estrogen receptors that are located in the plasma membrane, the effects of which are manifest in seconds to minutes instead of hours to days has revolutionized our thinking concerning the ways in which estrogens are likely to modulate pain responsiveness and the dynamic nature of that modulation. This review summarizes parameters of opioid functionality and nociception that are subject to modulation by estrogens, underscoring the added dimensions of such modulation that accrues from rapid membrane estrogen receptor signaling. Implications of this mode of signaling regarding putative sources of estrogens and its degradation are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.