Trial reportSleep medicine2013
Effect of continuous positive airway pressure on day/night rhythm of prothrombotic markers in obstructive sleep apnea.
Trial report in Sleep medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- From Molecular to Clinical Implications of Sleep-Related Breathing Disorders on the Treatment and Recovery of Acute Stroke: A Scoping Review.Current issues in molecular biology · 2025Review
- The Curious Role of PAI-1 in Severe Obstructive Sleep Apnea.Biomedicines · 2024Article
- Association of Plasma Biomarkers with Sleep Outcomes and Treatment Response After Mild Traumatic Brain Injury.Neurotrauma reports · 2023Article
- Endothelial dysfunction in obstructive sleep apnea patients.Sleep & breathing = Schlaf & Atmung · 2022Article
- Coagulation and Fibrinolysis in Obstructive Sleep Apnoea.International journal of molecular sciences · 2021Review
- Cardiovascular outcomes of continuous positive airway pressure therapy for obstructive sleep apnea.Journal of thoracic disease · 2018Review
- Obstructive sleep apnea might trigger acute pulmonary embolism: results from a cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Obstructive sleep apnea syndrome: coagulation anomalies and treatment with continuous positive airway pressure.Sleep & breathing = Schlaf & Atmung · 2016Review
- The role inflammatory response genes in obstructive sleep apnea syndrome: a review.Sleep & breathing = Schlaf & Atmung · 2016Review
- Effects of adenotonsillectomy on plasma inflammatory biomarkers in obese children with obstructive sleep apnea: A community-based study.International journal of obesity (2005) · 2015Article
- Serum levels of trace minerals and heavy metals in severe obstructive sleep apnea patients: correlates and clinical implications.Sleep & breathing = Schlaf & Atmung · 2015Article
- Pathophysiologic mechanisms of cardiovascular disease in obstructive sleep apnea syndrome.Pulmonary medicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveObstructive sleep apnea (OSA) has been associated with an increased risk of atherothrombotic events. A prothrombotic state might partially explain this link. This study investigated OSA patients' day/night rhythm of several prothrombotic markers and their potential changes with therapeutic continuous positive airway pressure (CPAP).
methodsThe study included 51 OSA patients [apnea hypopnea index (AHI) ⩾10] and 24 non-OSA controls (AHI<10). Of the 51 OSA patients, 25 were randomized to CPAP and 26 to placebo-CPAP. Twelve blood samples were collected over a 24h period to measure prothrombotic markers. For the apneic patients these samples were collected before treatment and after 3weeks of treatment with either CPAP or placebo-CPAP. Day/night variation in prothrombotic markers was examined using a cosinor analysis.
resultsCompared with controls, OSA patients showed lower mesor (mean) and amplitude (difference between maximum and minimum activity) of D-dimer. In unadjusted (but not in adjusted) analysis, patients showed higher mesor of plasminogen activator inhibitor-1 (p<0.05 in all cases). No significant group differences were seen in mesor and amplitude for either soluble tissue factor or von Willebrand factor, or the acrophase (time of the peak) and periodic pattern for any prothrombotic markers. There were no significant differences in changes of periodic pattern and in day/night rhythm parameters of prothrombotic markers pre- to post-treatment between the CPAP and placebo condition.
conclusionsThere may be altered day/night rhythm of some prothrombotic markers in OSA patients compared with controls. CPAP treatment for 3weeks did not affect day/night rhythm of prothrombotic markers in OSA patients differently from placebo-CPAP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.