ArticleHIV medicine2013
Ageing and long-term CD4 cell count trends in HIV-positive patients with 5 years or more combination antiretroviral therapy experience.
Article in HIV medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Immune non-response despite effective antiretroviral therapy in people living with HIV: A review of potential mechanisms, biomarkers and therapeutic approaches.HIV medicine · 2026Review
- Associations between breast radiation dermatitis and post-mastectomy pain syndrome in patients with breast cancer: A multicenter retrospective study.Asia-Pacific journal of oncology nursing · 2024Article
- Aging, trends in CD4+/CD8+ cell ratio, and clinical outcomes with persistent HIV suppression in a dynamic cohort of ambulatory HIV patients.AIDS (London, England) · 2022Article
- The effect of age on CD4+ T-cell recovery in HIV-suppressed adult participants: a sub-study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) study.Immunity & ageing : I & A · 2022Article
- Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini.Scientific reports · 2021Article
- Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm.Journal of neurovirology · 2019Review
- National characteristics and trends in antiretroviral treatment in Australia can be accurately estimated using a large clinical cohort.Journal of clinical epidemiology · 2018Article
- Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study.Annals of internal medicine · 2018Article
- Trends in CD4 cell count response to first-line antiretroviral treatment in HIV-positive patients from Asia, 2003-2013: TREAT Asia HIV Observational Database Low Intensity Transfer.International journal of STD & AIDS · 2017Article
- Immune recovery of middle-aged HIV patients following antiretroviral therapy: An observational cohort study.Medicine · 2017Observational
- CD4+/CD8+ ratio, age, and risk of serious noncommunicable diseases in HIV-infected adults on antiretroviral therapy.AIDS (London, England) · 2016Observational
- Article
- CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean.Open forum infectious diseases · 2015Article
- HIV and aging: insights from the Asia Pacific HIV Observational Database (APHOD).HIV medicine · 2015Observational
- Recent trends in early stage response to combination antiretroviral therapy in Australia.Antiviral therapy · 2015Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesThe aim of this study was to describe the long-term changes in CD4 cell counts beyond 5 years of combination antiretroviral therapy (cART). If natural ageing leads to a long-term decline in the immune system via low-grade chronic immune activation/inflammation, then one might expect to see a greater or earlier decline in CD4 counts in older HIV-positive patients with increasing duration of cART.
methodsRetrospective and prospective data were examined from long-term virologically stable HIV-positive adults from the Australian HIV Observational Database. We estimated mean CD4 cell count changes following the completion of 5 years of cART using linear mixed models.
resultsA total of 37 916 CD4 measurements were observed for 892 patients over a combined total of 9753 patient-years. Older patients (> 50 years old) at cART initiation had estimated mean (95% confidence interval) changes in CD4 counts by year-5 CD4 count strata (< 500, 500-750 and > 750 cells/μL) of 14 (7 to 21), 3 (-5 to 11) and -6 (-17 to 4) cells/μL/year. Of the CD4 cell count rates of change estimated, none were indicative of long-term declines in CD4 cell counts.
conclusionsOur results suggest that duration of cART and increasing age do not result in decreasing mean changes in CD4 cell counts for long-term virologically suppressed patients, indicating that the level of immune recovery achieved during the first 5 years of treatment is sustained through long-term cART.
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