ArticleBrain connectivity2012
Reduced functional connectivity of prefrontal regions and amygdala within affect and working memory networks in pediatric bipolar disorder.
Article in Brain connectivity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The impact of affective information on working memory: A pair of meta-analytic reviews of behavioral and neuroimaging evidence.Psychological bulletin · 2019Pooled it
- Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study.Psychiatry research · 2013Trial
- Alteration of fronto-thalamic-striatal and visual network activity to positive emotional stimuli in adolescent patients with bipolar disorder during a Go/No-Go task-based functional brain MRI.NeuroImage. Clinical · 2026Article
- Towards a neurodevelopmental model of bipolar disorder: a critical review of trait- and state-related functional neuroimaging in adolescents and young adults.Molecular psychiatry · 2025Review
- The association of genetic variation in CACNA1C with resting-state functional connectivity in youth bipolar disorder.International journal of bipolar disorders · 2023Article
- Does the Brain Matter? Cortical Alterations in Pediatric Bipolar Disorder: A Critical Review of Structural and Functional Magnetic Resonance Studies.Current neuropharmacology · 2023Review
- Neural function during emotion regulation and future depressive symptoms in youth at risk for affective disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Abnormal Degree Centrality Associated With Cognitive Dysfunctions in Early Bipolar Disorder.Frontiers in psychiatry · 2019Article
- The Abnormality of Topological Asymmetry in Hemispheric Brain Anatomical Networks in Bipolar Disorder.Frontiers in neuroscience · 2018Article
- Co-altered functional networks and brain structure in unmedicated patients with bipolar and major depressive disorders.Brain structure & function · 2017Article
- Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study.International journal of bipolar disorders · 2017Article
- Optogenetic Examination of Prefrontal-Amygdala Synaptic Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Dysfunctional gaze processing in bipolar disorder.NeuroImage. Clinical · 2017Article
- Abnormal Functional Connectivity Between Default and Salience Networks in Pediatric Bipolar Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Individualized identification of euthymic bipolar disorder using the Cambridge Neuropsychological Test Automated Battery (CANTAB) and machine learning.Journal of affective disorders · 2016Article
- Resting-state functional network connectivity in prefrontal regions differs between unmedicated patients with bipolar and major depressive disorders.Journal of affective disorders · 2016Article
- Intrinsic Amygdala Functional Connectivity in Youth With Bipolar I Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2015Article
- Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology.World journal of psychiatry · 2015Review
- Early signs of anomalous neural functional connectivity in healthy offspring of parents with bipolar disorder.Bipolar disorders · 2014Article
- Reward processing in healthy offspring of parents with bipolar disorder.JAMA psychiatry · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
This study examined whether adolescents with pediatric bipolar disorder (PBD) have abnormal regional functional connectivity in distributed brain networks during an affective working memory task. Adolescents with PBD (n=41) and healthy controls (HC; n=16) performed a two-back functional magnetic resonance imaging working memory task with blocks of either angry or neutral faces. Independent component analysis methodology identified two temporally independent and functionally connected brain networks that showed differential functional connectivity in PBD and HC. Within a network for "affect evaluation and regulation," PBD showed decreased functional connectivity relative to HC in regions involved in emotion processing such as the right amygdala, and in emotion regulation regions such as the right ventrolateral prefrontal cortex (VLPFC), while functional connectivity was increased in emotion evaluation regions such as the bilateral medial PFC. Furthermore, in an "Affective Working Memory Network," PBD exhibited greater connectivity relative to HC in left dorsolateral PFC (DLPFC), caudate, and right VLPFC; and simultaneously reduced connectivity in emotion processing regions, such as the right amygdala, bilateral temporal regions, and the junction of DLPFC/VLPFC, which interfaces affective and cognitive processes. Dysfunction in network engagement in PBD patients illustrates that they are expending greater effort in face emotion evaluation, while being less able to engage affect regulation regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.