ArticleJournal of the American Geriatrics Society2012
Effect of coexisting chronic obstructive pulmonary disease and cognitive impairment on health outcomes in older adults.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Impact of exercise training on cognitive function in patients with COPD: a systematic review and meta-analysis of randomised controlled trials.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Risk of dementia or cognitive impairment in COPD patients: A meta-analysis of cohort studies.Frontiers in aging neuroscience · 2022Pooled it
- Dementia and co-occurring chronic conditions: a systematic literature review to identify what is known and where are the gaps in the evidence?International journal of geriatric psychiatry · 2017Pooled it
- Cognitive impairment in COPD: a systematic review.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaPooled it
- Effects of 12 weeks of Head-Down Strong Abdominal Breathing Training on Gait and Cognitive Function in Patients with Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2025Trial
- Computerized screening for cognitive impairment in patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Trial
- Cognitive impairment in chronic respiratory disease patients using long-term oxygen therapy: a narrative review.Medical gas research · 2026Review
- Recognition and Management of Cognitive Impairment in Chronic Obstructive Pulmonary Disease (COPD): Implications of Clinical Confidence.Medicina (Kaunas, Lithuania) · 2026Review
- A Narrative Review of the Correlation Between Comorbidity and Acute Exacerbation of COPD Patients.International journal of chronic obstructive pulmonary disease · 2026Review
- Global Trends of Cognition-Targeted Interventions in Chronic Lung Disease: A Bibliometric and Visualized Analysis.International journal of chronic obstructive pulmonary disease · 2026Review
- Does Cognitive Function Influence the Benefits of Multicomponent Team Interventions?Journal of the American Medical Directors Association · 2026Article
- Effects of empowerment model-based telenursing interventions on empowerment in individuals with COPD.BMC nursing · 2025Article
- Development and validation of a nomogram for predicting the risk of cognitive impairment among chronic obstructive pulmonary diseases.Annals of medicine · 2025Article
- Managing cognitive impairment in patients with chronic obstructive pulmonary disease (COPD) in Saudi Arabia: what are the current practices?Annals of medicine · 2025Article
- Feasibility and acute physiological responses to supramaximal high-intensity interval training in COPD: a randomised crossover trial.ERJ open research · 2025Article
- Exploring the link: nutritional status and chronic obstructive pulmonary disease - insights from NHANES and clinical research.BMC pulmonary medicine · 2025Article
- Mesenchymal stem cell-derived exosomes-a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease.Stem cell research & therapy · 2025Review
- Construction and evaluation of nomogram for risk prediction of cognitive impairment in chronic obstructive pulmonary disease comorbidity.BMC psychology · 2025Article
- Healthcare Workers (HCWs)' Perceptions and Current Practice of Managing Cognitively Impaired Patients with Chronic Obstructive Pulmonary Disease (COPD).Medicina (Kaunas, Lithuania) · 2025Article
- Abnormal Brain Functional Connectivity in Patients with Chronic Obstructive Pulmonary Disease and Correlations with Clinical and Cognitive Parameters.International journal of chronic obstructive pulmonary disease · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesTo determine the extent to which the co-occurrence of chronic obstructive pulmonary disease (COPD) and cognitive impairment affect adverse health outcomes in older adults.
designMulticenter longitudinal cohort study.
settingCalifornia, Pennsylvania, Maryland, and North Carolina.
participantsThree thousand ninety-three community-dwelling adults aged 65 and older from the Cardiovascular Health Study. Four hundred thirty-one had chronic obstructive pulmonary disease (COPD) at study baseline. MEASUREMENTS: Follow-up began at the second CHS visit and continued for 3 years. Spirometric criteria for airflow limitation served to establish COPD using the Lambda-Mu-Sigma method, which accounts for age-related changes in lung function. Cognitive impairment was evaluated using the modified Mini-Mental State Examination and claims data. Outcomes were respiratory-related and all-cause hospitalizations and death.
resultsParticipants with coexisting COPD and cognitive impairment had the highest rates of respiratory-related (adjusted hazard ratio (aHR) = 4.10, 95% confidence interval (CI) = 1.86-9.05) and all-cause hospitalizations (aHR = 1.34, 95% CI = 1.00-1.80) and death (aHR = 2.29, 95% CI = 1.18-4.45). In particular, individuals with both conditions had a 48% higher rate of all-cause hospitalizations (adjusted synergy index (aSI) = 1.48, 95% CI = 0.19-11.31) and a rate of death nearly three times as high (aSI = 2.74, 95% CI = 0.43-17.32) as the sum of risks for each respective outcome associated with having COPD or cognitive impairment alone. Nevertheless, tests for interaction were not statistically significant for the presence of synergism between the two conditions contributing to each of the outcomes. Therefore, it cannot be concluded that the combined effect of COPD and cognitive impairment is greater than additive.
conclusionCoexisting COPD and cognitive impairment have an additive effect on respiratory-related and all-cause hospitalizations and death. Optimizing outcomes in older adults with COPD and cognitive impairment will require that how to improve concurrent management of both conditions be determined.
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