ArticleMolecular microbiology2012
LuxU connects quorum sensing to biofilm formation in Vibrio fischeri.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Strain matters: host responses reflect symbiont origin in the squid-vibrio symbiosis.mSystems · 2025Article
- A single point mutation is sufficient to driveJournal of bacteriology · 2025Article
- LitR and its quorum-sensing regulators modulate biofilm formation byJournal of bacteriology · 2025Article
- CerM and Its Antagonist CerN Are New Components of the Quorum Sensing System in Cereibacter sphaeroides, Signaling to the CckA/ChpT/CtrA System.MicrobiologyOpen · 2024Article
- A prototrophic suppressor of aJournal of bacteriology · 2024Article
- Review
- Perturbation of Quorum Sensing after the Acquisition of Bacteriophage Resistance Could Contribute to Novel Traits inMicroorganisms · 2023Article
- Two enhancer binding proteins activate σeLife · 2023Article
- The Antimicrobial Effect ofFrontiers in microbiology · 2022Article
- Control of Competence in Vibrio fischeri.Applied and environmental microbiology · 2021Article
- Quorum sensing inPeerJ · 2021Article
- Quorum Sensing and Cyclic di-GMP Exert Control Over Motility ofFrontiers in microbiology · 2021Article
- Natural Strain Variation Reveals Diverse Biofilm Regulation in Squid-ColonizingJournal of bacteriology · 2019Article
- Tools for Rapid Genetic Engineering of Vibrio fischeri.Applied and environmental microbiology · 2018Article
- Comparative analysis reveals regulatory motifs at the ainS/ainR pheromone-signaling locus of Vibrio fischeri.Scientific reports · 2017Article
- Article
- Integration of AI-2 Based Cell-Cell Signaling with Metabolic Cues in Escherichia coli.PloS one · 2016Article
- Antisocial luxO Mutants Provide a Stationary-Phase Survival Advantage in Vibrio fischeri ES114.Journal of bacteriology · 2015Article
- Identification of a novel matrix protein that promotes biofilm maturation in Vibrio fischeri.Journal of bacteriology · 2015Article
- Inhibition of Salmonella enterica biofilm formation using small-molecule adenosine mimetics.Antimicrobial agents and chemotherapy · 2015Article
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2 authors.
Funding
Abstract
Biofilm formation by Vibrio fischeri is a complex process involving multiple regulators, including the sensor kinase (SK) RscS and the response regulator (RR) SypG, which control the symbiosis polysaccharide (syp) locus. To identify other regulators of biofilm formation in V. fischeri, we screened a transposon library for mutants defective in wrinkled colony formation. We identified LuxQ as a positive regulator of syp-dependent biofilm formation. LuxQ is a member of the Lux phosphorelay and is predicted to control bioluminescence in concert with the SK AinR, the phosphotransferase LuxU and the RR LuxO. Of these, LuxU was the only other regulator that exerted a substantial impact on biofilm formation. We propose a model in which the Lux pathway branches at LuxU to control both bioluminescence and biofilm formation. Furthermore, our evidence suggests that LuxU functions to regulate syp transcription, likely by controlling SypG activity. Finally, we found that, in contrast to its predicted function, the SK AinR has little impact on bioluminescence under our conditions. Thus, this study reveals a novel connection between the Lux and Syp pathways in V. fischeri, and furthers our understanding of how the Lux pathway regulates bioluminescence in this organism.
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