ArticleBMC genomics2012
Analysis of the Lactobacillus casei supragenome and its influence in species evolution and lifestyle adaptation.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
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- Genomic insights into habitat adaptation of Lactobacillus species.World journal of microbiology & biotechnology · 2025Article
- New insight into protective effect against oxidative stress and biosynthesis of exopolysaccharides produced by Lacticaseibacillus paracasei NC4 from fermented eggplant.Current genetics · 2024Article
- Article
- Evaluation of Human Dental Plaque Lactic Acid Bacilli for Probiotic Potential and Functional Analysis in Relevance to Oral Health.Indian journal of microbiology · 2023Article
- Population genomics of Lacticaseibacillus paracasei: pan-genome, integrated prophage, antibiotic resistance, and carbohydrate utilization.World journal of microbiology & biotechnology · 2023Article
- Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus.Antimicrobial agents and chemotherapy · 2023Article
- Do nomadic lactobacilli fit as potential vaginal probiotics? The answer lies in a successful selective multi-step and scoring approach.Microbial cell factories · 2023Article
- Article
- Comparative genomics of Leuconostoc lactis strains isolated from human gastrointestinal system and fermented foods microbiomes.BMC genomic data · 2022Article
- Genotype to ecotype in niche environments: adaptation of Arthrobacter to carbon availability and environmental conditions.ISME communications · 2022Article
- Comparative genomic analysis ofFrontiers in microbiology · 2022Article
- Genomic Insight IntoFrontiers in microbiology · 2022Article
- Integrated Phenotypic-Genotypic Analysis ofFoods (Basel, Switzerland) · 2021Article
- Comprehensive Scanning of Prophages inmSystems · 2021Article
- Genome Sequencing of fiveMicroorganisms · 2021Article
- The food-gut axis: lactic acid bacteria and their link to food, the gut microbiome and human health.FEMS microbiology reviews · 2020Review
- Comparative Genomics ofGenes · 2020Article
- Comparative analysis of Lactobacillus gasseri from Chinese subjects reveals a new species-level taxa.BMC genomics · 2020Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe broad ecological distribution of L. casei makes it an insightful subject for research on genome evolution and lifestyle adaptation. To explore evolutionary mechanisms that determine genomic diversity of L. casei, we performed comparative analysis of 17 L. casei genomes representing strains collected from dairy, plant, and human sources.
resultsDifferences in L. casei genome inventory revealed an open pan-genome comprised of 1,715 core and 4,220 accessory genes. Extrapolation of pan-genome data indicates L. casei has a supragenome approximately 3.2 times larger than the average genome of individual strains. Evidence suggests horizontal gene transfer from other bacterial species, particularly lactobacilli, has been important in adaptation of L. casei to new habitats and lifestyles, but evolution of dairy niche specialists also appears to involve gene decay.
conclusionsGenome diversity in L. casei has evolved through gene acquisition and decay. Acquisition of foreign genomic islands likely confers a fitness benefit in specific habitats, notably plant-associated niches. Loss of unnecessary ancestral traits in strains collected from bacterial-ripened cheeses supports the hypothesis that gene decay contributes to enhanced fitness in that niche. This study gives the first evidence for a L. casei supragenome and provides valuable insights into mechanisms for genome evolution and lifestyle adaptation of this ecologically flexible and industrially important lactic acid bacterium. Additionally, our data confirm the Distributed Genome Hypothesis extends to non-pathogenic, ecologically flexible species like L. casei.
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