Trial reportTrials2012
Physical activity as an aid to smoking cessation during pregnancy (LEAP) trial: study protocol for a randomized controlled trial.
Trial report in Trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Exercise interventions for smoking cessation.The Cochrane database of systematic reviews · 2019Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2017Pooled it
- Systematic critical review of previous economic evaluations of smoking cessation during pregnancy.BMJ open · 2015Pooled it
- Yoga for prenatal depression: a systematic review and meta-analysis.BMC psychiatry · 2015Pooled it
- Psychosocial interventions for supporting women to stop smoking in pregnancy.The Cochrane database of systematic reviews · 2013Pooled it
- Physical activity for antenatal and postnatal depression in women attempting to quit smoking: randomised controlled trial.BMC pregnancy and childbirth · 2018Trial
- Effects of a Group-Mediated Exercise and Dietary Intervention in the Treatment of Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: Results From the IDEA-P Trial.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2018Trial
- Trial
- Physical activity for smoking cessation in pregnancy: randomised controlled trial.BMJ (Clinical research ed.) · 2015Trial
- Trial
- The effects of acute exercise on tobacco cravings and withdrawal symptoms in temporary abstinent pregnant smokers.Addictive behaviors · 2014Trial
- Smoking Cessation Advisors' Perspectives on Pregnant Women's Attitudes on the Risks and Consequences of Smoking While Pregnant.Healthcare (Basel, Switzerland) · 2025Article
- Trends in Physical Activity Research on Tobacco and/or Alcohol: A Bibliometric Analysis.Healthcare (Basel, Switzerland) · 2025Review
- The Great Disrupter: Relationship of Alexithymia to Emotion Regulation Processes and Smoking among Pregnant Women.Substance use & misuse · 2020Article
- Protocol for a two-arm feasibility RCT to support postnatal maternal weight management and positive lifestyle behaviour in women from an ethnically diverse inner city population: the SWAN feasibility trial.Pilot and feasibility studies · 2019Article
- Which measures of cigarette dependence are predictors of smoking cessation during pregnancy? Analysis of data from a randomized controlled trial.Addiction (Abingdon, England) · 2016Article
- Smoking during pregnancy: a difficult problem to face. Results of a French multi-center study.Journal of preventive medicine and hygiene · 2016Review
- Probing smoking craving with a multidimensional approach: validation of the 12-item French-language version of the Questionnaire on Smoking Urges.Neuropsychiatric disease and treatment · 2014Article
- Exercise-based smoking cessation interventions among women.Women's health (London, England) · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundMany women try to stop smoking in pregnancy but fail. One difficulty is that there is insufficient evidence that medications for smoking cessation are effective and safe in pregnancy and thus many women prefer to avoid these. Physical activity (PA) interventions may assist cessation; however, trials examining these interventions have been too small to detect or exclude plausible beneficial effects. The London Exercise And Pregnant smokers (LEAP) trial is investigating whether a PA intervention is effective and cost-effective when used for smoking cessation by pregnant women, and will be the largest study of its kind to date. METHODS/
designThe LEAP study is a pragmatic, multi-center, two-arm, randomized, controlled trial that will target pregnant women who smoke at least one cigarette a day (and at least five cigarettes a day before pregnancy), and are between 10 and 24 weeks pregnant. Eligible patients are individually randomized to either usual care (that is, behavioral support for smoking cessation) or usual care plus a intervention (entailing supervised exercise on a treadmill plus PA consultations). The primary outcome of the trial is self-reported and biochemically validated continuous abstinence from smoking between a specified quit date and the end of pregnancy. The secondary outcomes, measured at 1 and 4 weeks after the quit date, and at the end of pregnancy and 6 months after childbirth, are PA levels, depression, self-confidence, and cigarette withdrawal symptoms. Smoking status will also be self-reported at 6 months after childbirth. In addition, perinatal measures will be collected, including antenatal complications, duration of labor, mode of delivery, and birth and placental weight. Outcomes will be analyzed on an intention-to-treat basis, and logistic regression models used to compare treatment effects on the primary outcome. DISCUSSION: This trial will assess whether a PA intervention is effective when used for smoking cessation during pregnancy.
trial registrationISRCTN48600346.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.