ArticleMolecular & cellular proteomics : MCP2013
Activity-dependent protein dynamics define interconnected cores of co-regulated postsynaptic proteins.
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins.Nature communications · 2025Article
- Regulatory mechanisms in postsynaptic phosphorylation networks.Current opinion in structural biology · 2019Review
- Evolution of complexity in the zebrafish synapse proteome.Nature communications · 2017Article
- Vagal nerve stimulation modifies neuronal activity and the proteome of excitatory synapses of amygdala/piriform cortex.Journal of neurochemistry · 2017Article
- Counting numbers of synaptic proteins: absolute quantification and single molecule imaging techniques.Neurophotonics · 2016Review
- Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain.Journal of neurochemistry · 2016Article
- Neuroproteomics: How Many Angels can be Identified in an Extract from the Head of a Pin?Molecular & cellular proteomics : MCP · 2016Article
- Proteomics of the Synapse--A Quantitative Approach to Neuronal Plasticity.Molecular & cellular proteomics : MCP · 2016Review
- Glial Contributions to Neural Function and Disease.Molecular & cellular proteomics : MCP · 2016Review
- Mass Spectrometry-Based Approaches to Understand the Molecular Basis of Memory.Frontiers in chemistry · 2016Review
- Quantitative mass spectrometry measurements reveal stoichiometry of principal postsynaptic density proteins.Journal of proteome research · 2015Article
- Development of a highly automated and multiplexed targeted proteome pipeline and assay for 112 rat brain synaptic proteins.Proteomics · 2015Article
- Network and matrix analysis of the respiratory disease interactome.BMC systems biology · 2014Article
- The roles of protein expression in synaptic plasticity and memory consolidation.Frontiers in molecular neuroscience · 2014Review
- Recent advances in quantitative neuroproteomics.Methods (San Diego, Calif.) · 2013Review
- Proteomic analysis of postsynaptic density in Alzheimer's disease.Clinica chimica acta; international journal of clinical chemistry · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Synapses are highly dynamic structures that mediate cell-cell communication in the central nervous system. Their molecular composition is altered in an activity-dependent fashion, which modulates the efficacy of subsequent synaptic transmission events. Whereas activity-dependent trafficking of individual key synaptic proteins into and out of the synapse has been characterized previously, global activity-dependent changes in the synaptic proteome have not been studied. To test the feasibility of carrying out an unbiased large-scale approach, we investigated alterations in the molecular composition of synaptic spines following mass stimulation of the central nervous system induced by pilocarpine. We observed widespread changes in relative synaptic abundances encompassing essentially all proteins, supporting the view that the molecular composition of the postsynaptic density is tightly regulated. In most cases, we observed that members of gene families displayed coordinate regulation even when they were not known to physically interact. Analysis of correlated synaptic localization revealed a tightly co-regulated cluster of proteins, consisting of mainly glutamate receptors and their adaptors. This cluster constitutes a functional core of the postsynaptic machinery, and changes in its size affect synaptic strength and synaptic size. Our data show that the unbiased investigation of activity-dependent signaling of the postsynaptic density proteome can offer valuable new information on synaptic plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.