Trial reportAmerican journal of epidemiology2012
Physical activity reduces salt sensitivity of blood pressure: the Genetic Epidemiology Network of Salt Sensitivity Study.
Trial report in American journal of epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population.Journal of the American Heart Association · 2023Trial
- Relationship of Sodium Intake and Blood Pressure Varies With Energy Intake: Secondary Analysis of the DASH (Dietary Approaches to Stop Hypertension)-Sodium Trial.Hypertension (Dallas, Tex. : 1979) · 2018Trial
- Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.American journal of hypertension · 2018Trial
- Article
- Can We Protect Our Hearts by Sweating Out Excess Sodium?Exercise and sport sciences reviews · 2026Review
- Beyond the Average: Trends in Extreme Sodium Intake in the U.S. Population, 2003-2018.Nutrients · 2025Article
- Clinical guidelines for the diagnosis, evaluation, and management of hypertension for Korean children and adolescents: the Korean Working Group of Pediatric Hypertension.Kidney research and clinical practice · 2025Article
- Exercise as Vascular Medicine: Can Exercise Combat Negative Health Behaviors From Causing Endothelial Dysfunction?Exercise, sport & movement · 2025Article
- Pediatric Hypertension: A Condition That Matters.Children (Basel, Switzerland) · 2024Review
- Sodium and Human Health: What Can Be Done to Improve Sodium Balance beyond Food Processing?Nutrients · 2024Review
- Sodium, Interstitium, Lymphatics and Hypertension-A Tale of Hydraulics.Hypertension (Dallas, Tex. : 1979) · 2024Review
- Salty Subjects: Unpacking Racial Differences in Salt-Sensitive Hypertension.Current hypertension reports · 2024Review
- Association between salt sensitivity of blood pressure and the risk of hypertension in a Chinese Tibetan population.Journal of clinical hypertension (Greenwich, Conn.) · 2023Article
- Sodium intake and high blood pressure among adults on caloric deficit: a multi-year cross-sectional analysis of the U.S. population, 2007-2018.Journal of human hypertension · 2022Article
- Salt sensitivity of blood pressure in childhood and adolescence.Pediatric nephrology (Berlin, Germany) · 2022Review
- Advances in Genomics Research of Blood Pressure Responses to Dietary Sodium and Potassium Intakes.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Longitudinal association between physical activity and blood pressure, risk of hypertension among Chinese adults: China Health and Nutrition Survey 1991-2015.European journal of clinical nutrition · 2021Article
- Mechanisms of Dietary Sodium-Induced Impairments in Endothelial Function and Potential Countermeasures.Nutrients · 2021Review
- Pediatric hypertension: an updated review.Clinical hypertension · 2020Review
- Is alcohol drinking a key factor contributing to salt sensitivity?Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 2 countries.
Funding
Abstract
Salt sensitivity of blood pressure (BP) is influenced by genetic and environmental factors. A dietary feeding study was conducted from October 2003 to July 2005 that included a 7-day low-sodium intervention (51.3 mmol sodium/day) followed by a 7-day high-sodium intervention (307.8 mmol sodium/day) among 1,906 individuals who were 16 years of age or older and living in rural northern China. Salt sensitivity of BP was defined as mean BP change from the low-sodium intervention to the high-sodium intervention. Usual physical activity during the past 12 months was assessed at baseline using a standard questionnaire. The multivariable-adjusted means of systolic BP responses to high-sodium intervention were 5.21 mm Hg (95% confidence interval (CI): 4.55, 5.88), 4.97 mm Hg (95% CI: 4.35, 5.59), 5.02 mm Hg (95% CI: 4.38, 5.67), and 3.96 mm Hg (95% CI: 3.29, 4.63) among participants from the lowest to the highest quartiles of physical activity, respectively (P = 0.003 for linear trend). The multivariable-adjusted odds ratio of high salt sensitivity of systolic BP was 0.66 (95% CI: 0.49, 0.88) for persons in the highest quartile of physical activity compared with those in the lowest quartile. Physical activity is significantly, independently, and inversely related to salt sensitivity of BP and may be particularly effective in lowering BP among salt-sensitive individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.