ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Relationships Between Caffeine Intake and Risk for Probable Dementia or Global Cognitive Impairment: The Women's Health Initiative Memory Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Mouse Testing Methods in Psychoneuroimmunology: Measuring Behavioral Responses.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Characterisation of Primary Human Hippocampal Astrocyte Cell Culture Following Exposure to Hypoxia.The Malaysian journal of medical sciences : MJMS · 2023Article
- The link between cutaneous inflammation and cognitive impairment.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Review
- Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.Immunity · 2022Article
- Subfornical organ interleukin 1 receptor: A novel regulator of spontaneous and conditioned fear associated behaviors in mice.Brain, behavior, and immunity · 2022Article
- Analysing3 Biotech · 2021Article
- Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice.Frontiers in cellular neuroscience · 2020Article
- HFD refeeding in mice after fasting impairs learning by activating caspase-1 in the brain.Metabolism: clinical and experimental · 2020Article
- Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling.Brain, behavior, and immunity · 2019Article
- Nutritional psychoneuroimmunology: Is the inflammasome a critical convergence point for stress and nutritional dysregulation?Current opinion in behavioral sciences · 2019Article
- Hypoxia-Induced Neuroinflammation and Learning-Memory Impairments in Adult Zebrafish Are Suppressed by Glucosamine.Molecular neurobiology · 2018Article
- Nasal administration of mesenchymal stem cells restores cisplatin-induced cognitive impairment and brain damage in mice.Oncotarget · 2018Article
- Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities.Nutrition & metabolism · 2018Article
- Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation.Metabolic brain disease · 2017Article
- Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.Metabolism: clinical and experimental · 2017Article
- Pifithrin-μ Prevents Cisplatin-Induced Chemobrain by Preserving Neuronal Mitochondrial Function.Cancer research · 2017Article
- Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia.The Journal of physiology · 2016Review
- The Effects of Hypoxia and Inflammation on Synaptic Signaling in the CNS.Brain sciences · 2016Review
- Short-Term High-Fat Diet (HFD) Induced Anxiety-Like Behaviors and Cognitive Impairment Are Improved with Treatment by Glyburide.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
Abstract
After hypoxia, a critical adverse outcome is the inability to create new memories. How anterograde amnesia develops or resolves remains elusive, but a link to brain-based IL-1 is suggested due to the vital role of IL-1 in both learning and brain injury. We examined memory formation in mice exposed to acute hypoxia. After reoxygenation, memory recall recovered faster than memory formation, impacting novel object recognition and cued fear conditioning but not spatially cued Y-maze performance. The ability of mice to form new memories after hypoxia/reoxygenation was accelerated in IL-1 receptor 1 knockout (IL-1R1 KO) mice, in mice receiving IL-1 receptor antagonist (IL-1RA), and in mice given the caspase 1 inhibitor Ac-YVAD-CMK. Mechanistically, hypoxia/reoxygenation more than doubled caspase 1 activity in the brain, which was localized to the amygdala compared to the hippocampus. This reoxygenation-dependent activation of caspase 1 was prevented by broad-spectrum adenosine receptor (AR) antagonism with caffeine and by targeted A1/A2A AR antagonism with 8-cyclopentyl-1,3-dipropylxanthine plus 3,7-dimethyl-1-propargylxanthine. Additionally, perfusion of adenosine activated caspase 1 in the brain, while caffeine blocked this action by adenosine. Finally, resolution of anterograde amnesia was improved by both caffeine and by targeted A1/A2A AR antagonism. These findings indicate that amygdala-based anterograde amnesia after hypoxia/reoxygenation is sustained by IL-1β generated through adenosine-dependent activation of caspase 1 after reoxygenation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.