ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2012
Biasing amacrine subtypes in the Atoh7 lineage through expression of Barhl2.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
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- 'Iterative Bleaching Extends Multiplexity' facilitates simultaneous identification of all major retinal cell types.Journal of cell science · 2024Article
- Deterministic and probabilistic fate decisions co-exist in a single retinal lineage.The EMBO journal · 2023Article
- GliaMorph: a modular image analysis toolkit to quantify Müller glial cell morphology.Development (Cambridge, England) · 2023Article
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- Genetic control of retinal ganglion cell genesis.Cellular and molecular life sciences : CMLS · 2021Review
- T-Cell Factors as Transcriptional Inhibitors: Activities and Regulations in Vertebrate Head Development.Frontiers in cell and developmental biology · 2021Review
- Transcriptome analysis of the zebrafishFASEB bioAdvances · 2020Article
- Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain.Scientific reports · 2020Article
- Article
- Notch signalling patterns retinal composition by regulatingDevelopment (Cambridge, England) · 2018Article
- Fate bias during neural regeneration adjusts dynamically without recapitulating developmental fate progression.Neural development · 2017Article
- Regulation ofDevelopment (Cambridge, England) · 2017Article
- In Vivo Imaging of Transgenic Gene Expression in Individual Retinal Progenitors in Chimeric Zebrafish Embryos to Study Cell Nonautonomous Influences.Journal of visualized experiments : JoVE · 2017Article
- The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages.PloS one · 2017Article
- Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo.BMC neuroscience · 2016Article
- Independent modes of ganglion cell translocation ensure correct lamination of the zebrafish retina.The Journal of cell biology · 2016Article
- Inhibitory neuron migration and IPL formation in the developing zebrafish retina.Development (Cambridge, England) · 2015Article
- Cavefish eye loss in response to an early block in retinal differentiation progression.Development (Cambridge, England) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 5 countries.
Funding
Abstract
Within the developing vertebrate retina, particular subtypes of amacrine cells (ACs) tend to arise from progenitors expressing the basic helix-loop-helix (bHLH) transcription factor, Atoh7, which is necessary for the early generation of retinal ganglion cells (RGCs). All ACs require the postmitotic expression of the bHLH pancreas transcription factor Ptf1a; however, Ptf1a alone is not sufficient to give subtype identities. Here we use functional and in vivo time-lapse studies in the zebrafish retina to investigate on the developmental programs leading to ACs specification within the subsequent divisions of Atoh7-positive progenitors. We find evidences that the homeobox transcription factor Barhl2 is an AC subtype identity-biasing factor that turns on within Atoh7-positive descendants. In vivo lineage tracing reveals that particular modes of cell division tend to generate Barhl2-positive precursors from sisters of RGCs. Additionally, Atoh7 indirectly impacts these division modes to regulate the right number of barhl2-expressing cells. We finally find that Atoh7 itself influences the subtypes of Barhl2-dependent ACs. Together, the results from our study uncover lineage-related and molecular logic of subtype specification in the vertebrate retina, by showing that specific AC subtypes arise via a particular mode of cell division and a transcriptional network cascade involving the sequential expression of first atoh7 followed by ptf1a and then barhl2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.