ArticleNucleic acids research2012
SR1--a small RNA with two remarkably conserved functions.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Protein Functional Effector (pfe) Noncoding RNAS Are Identical to Fragments from Various Noncoding RNAs.International journal of molecular sciences · 2025Article
- Review
- Small proteins in Gram-positive bacteria.FEMS microbiology reviews · 2023Article
- Article
- The sRNA NsiR4 fine-tunes arginine synthesis in the cyanobacteriumRNA biology · 2022Article
- A new role for SR1 from Bacillus subtilis: regulation of sporulation by inhibition of kinA translation.Nucleic acids research · 2021Article
- Review
- Identification of an RNA sponge that controls the RoxS riboregulator of central metabolism in Bacillus subtilis.Nucleic acids research · 2021Article
- Moonlighting inMicroorganisms · 2021Review
- SR7 - a dual-function antisense RNA fromRNA biology · 2021Article
- Multiple information carried by RNAs: total eclipse or a light at the end of the tunnel?RNA biology · 2020Review
- Intermolecular Communication inFrontiers in molecular biosciences · 2020Review
- AtxA-Controlled Small RNAs ofFrontiers in microbiology · 2020Article
- A new role for CsrA: promotion of complex formation between an sRNA and its mRNA target inRNA biology · 2019Article
- A multifaceted small RNA modulates gene expression upon glucose limitation inThe EMBO journal · 2019Article
- Transcriptome based Identification of silver stress responsive sRNAs from Bacillus cereus ATCC14579.Bioinformation · 2019Article
- Dual-Function RNAs.Microbiology spectrum · 2018Review
- Bacterial fumarase and L-malic acid are evolutionary ancient components of the DNA damage response.eLife · 2017Article
- Regulatory RNAs in Bacillus subtilis: a Gram-Positive Perspective on Bacterial RNA-Mediated Regulation of Gene Expression.Microbiology and molecular biology reviews : MMBR · 2016Review
- Small proteins in cyanobacteria provide a paradigm for the functional analysis of the bacterial micro-proteome.BMC microbiology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SR1 is a dual-function sRNA that acts as a base-pairing regulatory RNA on the ahrC mRNA and as a peptide-encoding mRNA on the gapA operon. The SR1-encoded peptide SR1P binds GapA thereby stabilizing gapA mRNA. Under glycolytic conditions, SR1 transcription is repressed by CcpN and CcpA. A computer-based search identified 23 SR1 homologues in Bacillus, Geobacillus, Anoxybacillus and Brevibacillus species. All homologues share a high structural identity with Bacillus subtilis SR1, and the encoded SR1P peptides are highly similar. In the Bacillus cereus group, the sr1p region is present in triplicate or duplicate resulting in longer SR1 species. In all cases, sr1 expression is under control of CcpN, and transcriptional lacZ fusions of nine examined SR1 homologues were sensitive to glucose. Two homologues showed an additional glucose-independent repression by CcpN and an unknown factor. A total of 10 out of 11 tested SR1P homologues complemented a B. subtilis Δsr1 strain in their ability to stabilize gapA mRNA, but only five of them bound GapA tightly. In vitro binding assays with six SR1/ahrC pairs suggest that-despite divergent primary sequences-the base-pairing function is also preserved. In summary, SR1 is an sRNA with two functions that have been conserved over ≈1 billion years.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.