ArticleProceedings. Biological sciences2012
Constraints on the coevolution of contemporary human males and females.
Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review reveals multiple sexually antagonistic polymorphisms affecting human disease and complex traits.Evolution; international journal of organic evolution · 2021Pooled it
- Assortative mating for human height: A meta-analysis.American journal of human biology : the official journal of the Human Biology Council · 2017Pooled it
- The maintenance of genetic polymorphism underlying sexually antagonistic traits.Evolution letters · 2025Article
- Natural selection on reproductive timing varies by education in twentieth-century Estonia.Evolutionary human sciences · 2025Article
- The battle of the sexes in humans is highly polygenic.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Sex-limited chromosomes and non-reproductive traits.BMC biology · 2022Review
- An unbiased test reveals no enrichment of sexually antagonistic polymorphisms on the human X chromosome.Proceedings. Biological sciences · 2022Article
- The search for sexually antagonistic genes: Practical insights from studies of local adaptation and statistical genomics.Evolution letters · 2020Article
- Frontiers in Molecular Evolutionary Medicine.Journal of molecular evolution · 2020Review
- Assortative mating at loci under recent natural selection in humans.Bio Systems · 2020Article
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- Morphometric traits predict educational attainment independently of socioeconomic background.BMC public health · 2019Article
- Quantifying maladaptation during the evolution of sexual dimorphism.Proceedings. Biological sciences · 2019Article
- Cross-sex genetic correlations for fitness and fitness components: Connecting theoretical predictions to empirical patterns.Evolution letters · 2019Article
- Evidence of directional and stabilizing selection in contemporary humans.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice.Trends in neurosciences · 2016Review
- Reduced costs of reproduction in females mediate a shift from a male-biased to a female-biased lifespan in humans.Scientific reports · 2016Article
Corrections and comments
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4 authors.
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Abstract
Because autosomal genes in sexually reproducing organisms spend on average half their time in each sex, and because the traits that they influence encounter different selection pressures in males and females, the evolutionary responses of one sex are constrained by processes occurring in the other sex. Although intralocus sexual conflict can restrict sexes from reaching their phenotypic optima, no direct evidence currently supports its operation in humans. Here, we show that the pattern of multivariate selection acting on human height, weight, blood pressure and glucose, total cholesterol, and age at first birth differs significantly between males and females, and that the angles between male and female linear (77.8 ± 20.5°) and nonlinear (99.1 ± 25.9°) selection gradients were closer to orthogonal than zero, confirming the presence of sexually antagonistic selection. We also found evidence for intralocus sexual conflict demonstrated by significant changes in the predicted male and female responses to selection of individual traits when cross-sex genetic covariances were included and a significant reduction in the angle between male- and female-predicted responses when cross-sex covariances were included (16.9 ± 15.7°), compared with when they were excluded (87.9 ± 31.6°). We conclude that intralocus sexual conflict constrains the joint evolutionary responses of the two sexes in a contemporary human population.
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