ArticleJournal of Alzheimer's disease : JAD2013
Soy-based diet exacerbates seizures in mouse models of neurological disease.
Article in Journal of Alzheimer's disease : JAD, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Stearoyl-CoA desaturase-1 is vital for milk lipid synthesis: Deletion impairs mammary gland and neonatal development.Journal of lipid research · 2025Article
- Soy Protein Isolate Affects Blood and Brain Biomarker Expression in a Mouse Model of Fragile X.International journal of molecular sciences · 2025Article
- Soy-based purified ingredient diet affects mouse gut permeability and the microbiome in fragile X mice.Frontiers in molecular neuroscience · 2025Article
- Effects of Soy Protein Isolate on Fragile X Phenotypes in Mice.Nutrients · 2024Article
- On-Tissue Spatial Proteomics Integrating MALDI-MS Imaging with Shotgun Proteomics Reveals Soy Consumption-Induced Protein Changes in a Fragile X Syndrome Mouse Model.ACS chemical neuroscience · 2024Article
- Improving Reproducibility to Enhance Scientific Rigor through Consideration of Mouse Diet.Animals : an open access journal from MDPI · 2022Article
- Effects of Soy-Based Infant Formula on Weight Gain and Neurodevelopment in an Autism Mouse Model.Cells · 2022Article
- A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer.Ecotoxicology and environmental safety · 2022Article
- Diet in treatment of autism spectrum disorders.Frontiers in neuroscience · 2022Review
- Parental Reports on Early Autism Behaviors in Their Children with Fragile X Syndrome as a Function of Infant Feeding.Nutrients · 2021Article
- Consumption of Breast Milk Is Associated with Decreased Prevalence of Autism in Fragile X Syndrome.Nutrients · 2021Article
- The Influence of Feed and Drinking Water on Terrestrial Animal Research and Study Replicability.ILAR journal · 2020Article
- Soy-Based Infant Formula is Associated with an Increased Prevalence of Comorbidities in Fragile X Syndrome.Nutrients · 2020Article
- Preclinical testing of the ketogenic diet in fragile X mice.Neurochemistry international · 2020Article
- Fragile X and APP: a Decade in Review, a Vision for the Future.Molecular neurobiology · 2019Review
- Early impacts of modified food consistency on oromotor outcomes in mouse models of Down syndrome.Physiology & behavior · 2019Article
- Article
- Genistein modulation of seizure: involvement of estrogen and serotonin receptors.Journal of natural medicines · 2017Article
- APP Causes Hyperexcitability in Fragile X Mice.Frontiers in molecular neuroscience · 2016Article
- Soy-Based Therapeutic Baby Formulas: Testable Hypotheses Regarding the Pros and Cons.Frontiers in nutrition · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Seizures are a common phenotype in many neurological disorders including Alzheimer's disease, Down syndrome, and fragile X syndrome. Mouse models of these disorders overexpress amyloid-β protein precursor (AβPP) and amyloid-β (Aβ) and are highly susceptible to audiogenic-induced seizures (AGS). We observed decreased AGS in these mice fed a casein-based, purified diet (D07030301) as opposed to a standard soy protein-containing, non-purified diet (Purina 5015). Our objective in this manuscript was to determine if soy protein, and in particular soy isoflavones, in the Purina 5015 were contributing to the seizure phenotype. Wild running, AGS, and death rates were assessed in juvenile mice fed Purina 5015, D07030301, D07030301 containing soy protein, or D07030301 supplemented with individual isoflavones (750 mg/kg daidzein or genistein). A short treatment (3 days) with Purina 5015 induced wild running and AGS in Alzheimer's disease mice. A 3-day treatment with daidzein-supplemented diet, but not genistein, induced wild running in wild type mice. To understand the mechanism underlying daidzein activity, we assessed dendritic AβPP expression in primary, cultured, wild type neurons treated with daidzein or genistein. In vitro, daidzein significantly increased dendritic AβPP. Thus, the soy isoflavone daidzein recapitulated seizure induction in vivo and altered AβPP expression in vitro. These results have important implications for individuals on soy-based diets as well as for rodent model research.
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Registered trials
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