ArticleNeuroImage2012
5-HTTLPR-environment interplay and its effects on neural reactivity in adolescents.
Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Underlying Mechanisms of Gene-Environment Interactions in Externalizing Behavior: A Systematic Review and Search for Theoretical Mechanisms.Clinical child and family psychology review · 2015Pooled it
- The Early Emotional Bond: An Evolutionary-Developmental Perspective Integrating Psychoanalysis, Neuroscience, and Cross-Cultural Evidence.Brain sciences · 2026Review
- How biopsychosocial depressive risk shapes behavioral and neural responses to social evaluation in adolescence.Brain and behavior · 2021Article
- Mood and neural responses to social rejection do not seem to be altered in resilient adolescents with a history of adversity.Development and psychopathology · 2020Article
- Article
- Gene-environment Interactions in Late Life: Linking Psychosocial Stress with Brain Aging.Current neuropharmacology · 2018Review
- Parenting and adolescents' psychological adjustment: Longitudinal moderation by adolescents' genetic sensitivity.Development and psychopathology · 2017Article
- Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms.Translational psychiatry · 2016Article
- The ROOTS study: a 10-year review of findings on adolescent depression, and recommendations for future longitudinal research.Social psychiatry and psychiatric epidemiology · 2016Review
- Major Depressive Disorder Among Children and Adolescents.Focus (American Psychiatric Publishing) · 2016Article
- Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events.The American journal of psychiatry · 2015Article
- Adolescents with current major depressive disorder show dissimilar patterns of age-related differences in ACC and thalamus.NeuroImage. Clinical · 2015Article
- 5-HTTLPR Expression Outside the Skin: An Experimental Test of the Emotional Reactivity Hypothesis in Children.PloS one · 2015Article
- Serotonin transporter gene promoter polymorphism (5-HTTLPR) and alcohol use in general population: interaction effect with birth cohort.Psychopharmacology · 2014Article
- Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing.Social cognitive and affective neuroscience · 2014Article
- General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.NeuroImage. Clinical · 2014Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
It is not known how 5-HTTLPR genotype x childhood adversity (CA) interactions that are associated with an increased risk for affective disorders in population studies operate at the neural systems level. We hypothesized that healthy adolescents at increased genetic and environmental risk for developing mood disorders (depression and anxiety) would demonstrate increased amygdala reactivity to emotional stimuli compared to those with only one such risk factor or those with none. Participants (n=67) were classified into one of 4 groups dependent on being homozygous for the long or short alleles within the serotonin-transporter-linked polymorphic region (5-HTTLPR) of the SLC6A4 gene and exposure to CA in the first 11 years of life (present or absent). A functional magnetic resonance imaging investigation was undertaken which involved viewing emotionally-salient face stimuli. In addition, we assessed the role of other variables hypothesized to influence amygdala reactivity, namely recent negative life-events (RNLE) assessed at ages 14 and 17, current anxiety symptoms and psychiatric history. We replicated prior findings demonstrating moderation by gene variants in 5-HTTLPR, but found no support for an effect of CA on amygdala reactivity. We also found a significant effect of RNLE aged 17 with amygdala reactivity demonstrating additive, but not interactive effects with 5-HTTLPR. A whole-brain analysis found a 5-HTTLPR×CA interaction in the lingual gyrus whereby CA appears to differentially modify neural reactivity depending on genotype. These results demonstrate that two different forms of environmental adversities interplay with 5-HTTLPR and thereby differentially impact amygdala and cortical reactivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.