ArticleBlood2012
Mouse natural killer cell development and maturation are differentially regulated by SHIP-1.
Article in Blood, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.Science advances · 2021Article
- Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells.Cellular & molecular immunology · 2021Article
- Chemical functionality of multidomain peptide hydrogels governs early host immune response.Biomaterials · 2020Article
- Article
- Molecular Regulation of NK Cell Maturation.Frontiers in immunology · 2020Review
- Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.Nature communications · 2019Article
- Natural Killer Cell Education and the Response to Infection and Cancer Therapy: Stay Tuned.Trends in immunology · 2018Review
- Regulation of Hematopoietic Cell Development and Function Through Phosphoinositides.Frontiers in immunology · 2018Review
- Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.Frontiers in immunology · 2018Review
- Transcription factor KLF2 regulates homeostatic NK cell proliferation and survival.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Role of SHIP1 in Invariant NKT Cell Development and Functions.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- SHIP1 intrinsically regulates NK cell signaling and education, resulting in tolerance of an MHC class I-mismatched bone marrow graft in mice.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- PTEN regulates natural killer cell trafficking in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells.Molecular and cellular biology · 2015Article
- Dok1 and Dok2 proteins regulate natural killer cell development and function.The EMBO journal · 2014Article
- T-cell immunoglobulin and ITIM domain (TIGIT) receptor/poliovirus receptor (PVR) ligand engagement suppresses interferon-γ production of natural killer cells via β-arrestin 2-mediated negative signaling.The Journal of biological chemistry · 2014Article
- Article
- MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling.Blood · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The SH2-containing inositol phosphatase-1 (SHIP-1) is a 5' inositol phosphatase known to negatively regulate the product of phosphoinositide-3 kinase (PI3K), phosphatidylinositol-3.4,5-trisphosphate. SHIP-1 can be recruited to a large number of inhibitory receptors expressed on natural killer (NK) cells. However, its role in NK cell development, maturation, and functions is not well defined. In this study, we found that the absence of SHIP-1 results in a loss of peripheral NK cells. However, using chimeric mice we demonstrated that SHIP-1 expression is not required intrinsically for NK cell lineage development. In contrast, SHIP-1 is required cell autonomously for NK cell terminal differentiation. These findings reveal both a direct and indirect role for SHIP-1 at different NK cell development checkpoints. Notably, SHIP-1-deficient NK cells display an impaired ability to secrete IFN-γ during cytokine receptor-mediated responses, whereas immunoreceptor tyrosine-based activation motif containing receptor-mediated responses is not affected. Taken together, our results provide novel insights on how SHIP-1 participates in the development, maturation, and effector functions of NK cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.