ArticleGenome biology2012
The landscape of DNA repeat elements in human heart failure.
Article in Genome biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.Cardiovascular research · 2017Guideline
- Cardiovascular risks and hazards associated with deep space exploration.Communications medicine · 2026Review
- Role of Perturbations of Epigenetic Processes in Cardiac Hypertrophy and Fibrotic Scarring.Current cardiology reviews · 2026Review
- α-Hemolysin from Staphylococcus aureus Changes the Epigenetic Landscape of Th17 Cells.ImmunoHorizons · 2024Article
- DNA methylome and transcriptome profiling reveal key electrophysiology and immune dysregulation in hypertrophic cardiomyopathy.Epigenetics · 2023Article
- Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure.Basic research in cardiology · 2023Article
- Contribution of DNA methylation in chronic stress-induced cardiac remodeling and arrhythmias in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (Life sciences in space research · 2019Article
- DMSO induces drastic changes in human cellular processes and epigenetic landscape in vitro.Scientific reports · 2019Article
- Multi-omic analysis of signalling factors in inflammatory comorbidities.BMC bioinformatics · 2018Article
- Comparative Analysis of Satellite DNA in theG3 (Bethesda, Md.) · 2017Article
- Epigenetics in heart failure phenotypes.BBA clinical · 2016Review
- DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy.Nature communications · 2016Article
- Epigenetic regulation in heart failure.Current opinion in cardiology · 2016Review
- Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart.Mutation research · 2016Article
- In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung.Life sciences in space research · 2015Article
- Epigenetic modifications and noncoding RNAs in cardiac hypertrophy and failure.Nature reviews. Cardiology · 2015Review
- Heart failure: advanced development in genetics and epigenetics.BioMed research international · 2015Review
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe epigenomes of healthy and diseased human hearts were recently examined by genome-wide DNA methylation profiling. Repetitive elements, heavily methylated in post-natal tissue, have variable methylation profiles in cancer but methylation of repetitive elements in the heart has never been examined.
resultsWe analyzed repetitive elements from all repeat families in human myocardial samples, and found that satellite repeat elements were significantly hypomethylated in end-stage cardiomyopathic hearts relative to healthy normal controls. Satellite repeat elements are almost always centromeric or juxtacentromeric, and their overexpression correlates with disease aggressiveness in cancer. Similarly, we found that hypomethylation of satellite repeat elements correlated with up to 27-fold upregulation of the corresponding transcripts in end-stage cardiomyopathic hearts. No other repeat family exhibited differential methylation between healthy and cardiomyopathic hearts, with the exception of the Alu element SINE1/7SL, for which a modestly consistent trend of increased methylation was observed.
conclusionsSatellite repeat element transcripts, a form of non-coding RNA, have putative functions in maintaining genomic stability and chromosomal integrity. Further studies will be needed to establish the functional significance of these non-coding RNAs in the context of heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.