ArticleThe New England journal of medicine2012
The prevention and treatment of missing data in clinical trials.
3 registry-linked trialsAbstract read
In one paragraph
Article in The New England journal of medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 742 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
742citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Symptom Management, Quality of Life and Satisfaction With Care for Advanced Stage Cancers - Control Arm
Closed Incision Negative Pressure Therapy Compared to Conventional Dressing Following Autologous Abdominal Tissue Breast Reconstruction: A Pilot Randomized Control Trial
Comparative Effectiveness of Individual Versus Group-level Interventions to Reduce HIV Risk Among African Immigrant Women
Who cites it
742 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Multiple imputation in clinical trials - what difference does it make? A systematic review of the impact of multiple imputation on treatment effect estimation.Clinical trials (London, England) · 2026Pooled it
- Research Review: Mechanisms of change and between-family differences in parenting interventions for children with ADHD - an individual participant data meta-analysis.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Handling Missing Data in Health Economics and Outcomes Research (HEOR): A Systematic Review and Practical Recommendations.PharmacoEconomics · 2023Pooled it
- Trial
- The Effect of 6 Months of Dietary Counselling on Sleep Outcomes Among Patients With Cardiovascular Diseases: A Randomised Controlled Trial.Journal of sleep research · 2026Trial
- Cerebral Oximetry in Extremely Preterm Infants: 2-Year Follow-Up of the SafeBoosC-III Randomized Clinical Trial.JAMA pediatrics · 2026Trial
- Mode Effects Between Mobile Web and Telephone Surveys on Patient Experience Scores in South Korea: Secondary Analysis of a Randomized Controlled Trial Under Various Missingness Scenarios.Journal of medical Internet research · 2026Trial
- Enhanced Weight Management Program for Veterans With Posttraumatic Stress Disorder: A Randomized Clinical Trial.JAMA network open · 2026Trial
- Randomized Controlled Trial of a Group Cognitive Behavior Therapy HIV Prevention Intervention for Immigrant Latino Gay, Bisexual, and Other Men who Have Sex with Men.AIDS and behavior · 2026Trial
- Smartphone cognitive behavioral therapy for prevention of depressive symptoms in patients with recurrent pregnancy loss: an exploratory decentralized, parallel-group, multicenter, open, individually randomized, fully factorial trial.Psychiatry and clinical neurosciences · 2026Trial
- Evaluating the Cultural Adaptation of Evidence-Based HIV Prevention Interventions for African Immigrant Women: Exploratory Pilot Mixed-Methods Study.Journal of immigrant and minority health · 2026Trial
- Once and thrice weekly interval training in adults with central obesity: a randomized controlled trial.Nature communications · 2026Trial
- Short-Term Audiometric Trajectories in Older Adults Receiving Systemic Human Umbilical Cord-Derived Mesenchymal Stem Cells: An Exploratory Single-Arm Substudy.Clinical interventions in aging · 2026Trial
- The cost of drug repurposing: parallel economic evaluation of mirtazapine for severe breathlessness in the multinational BETTER-B trial.BMC health services research · 2025Trial
- An educational tool to improve PREeclamPsia knowledge and Aspirin adheRence in lupus prEgnancies: the PREPARE trial.Rheumatology (Oxford, England) · 2025Trial
- Evaluating the Sustaining Play, Sustaining Health programme in Australian early childhood education and care services: a pilot randomized controlled trial.Health promotion international · 2025Trial
- Enhancing group lifestyle intervention for depression with ecological momentary assessment: a pilot randomized controlled trial.Scientific reports · 2025Trial
- Recruitment and retention in a preclinical AD trial: comparisons between academic and non-academic sites.Alzheimer's research & therapy · 2025Trial
- Testing Theory-Enhanced Messaging to Promote COVID-19 Vaccination Among Adults: Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Early Emotion Development Intervention Improves Mental Health Outcomes in Low-Income, High-Risk Community Children.Child psychiatry and human development · 2025Trial
682 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Roderick J LittleDepartment of Biostatistics, University of Michigan, Ann Arbor, USA.
Ralph D'Agostino
Michael L Cohen
Kay Dickersin
Scott S Emerson
John T Farrar
Constantine Frangakis
Joseph W Hogan
Geert Molenberghs
Susan A Murphy
James D Neaton
Andrea Rotnitzky
Daniel Scharfstein
Weichung J Shih
Jay P Siegel
Hal Stern
Funding
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7MTHE REFINEMENT &APPLICATION OF MEDICAL DECISION MAKING IN PREVENTION SCIENCESP50DA010075 · NIDA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LANZA, STEPHANIE T · 1996 to 2014
$24.5MVirology CoreP01AA019072 · NIAAA · BROWN UNIVERSITY · PI BECKER, SARA · 2010 to 2024
$19.7MLearning Adaptive Treatment Strategies in Mental HealthR01MH080015 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURPHY, SUSAN A · 2007 to 2011
$2.2MStatistical Designs and Methods for Double-Sampling for HIV/AIDSR01AI102710 · NIAID · JOHNS HOPKINS UNIVERSITY · PI FRANGAKIS, CONSTANTINE E · 2013 to 2016
$1.6MNew Approaches to Mediation Analysis using Causal Inference MethodsRC1AA019186 · NIAAA · BROWN UNIVERSITY · PI HOGAN, JOSEPH W · 2009 to 2010
$940kNIAAA NIH HHS P01 AA019072NIAAA NIH HHS RC1 AA019186NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI102710NIDA NIH HHS P50 DA010075NIMH NIH HHS R01 MH080015
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clinical Trials as TopicClinical Trials, Phase III as TopicData CollectionIntention to Treat AnalysisResearch Design
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.