ArticleTransfusion2013
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia.
Article in Transfusion, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Immune landscape in liver of neonatal mice with phlebotomy-induced anemia.Pediatric research · 2026Article
- Microtubular Disruption Alters Intestinal Permeability in Murine Neonatal Anemic Intestine.Anemia · 2026Article
- Early plasma ferritin concentrations are not associated with time to red cell transfusions in extremely and very preterm neonates: a prospective single-site observational study.BMJ paediatrics open · 2025Observational
- Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Red Blood Cell Transfusion in European Neonatal Intensive Care Units, 2022 to 2023.JAMA network open · 2024Observational
- A Detailed Protocol for the Induction of Anemia and RBC Transfusion-associated Necrotizing Enterocolitis in Neonatal Mice.Bio-protocol · 2024Article
- Placental transfusion: may the "force" be with the baby.Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Are single-donor red blood cell transfusions still relevant for preterm infants?Journal of perinatology : official journal of the California Perinatal Association · 2020Article
- Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Neonatal clinical blood sampling led to major blood loss and was associated with bronchopulmonary dysplasia.Acta paediatrica (Oslo, Norway : 1992) · 2020Article
- Neonatal Umbilical Arterial Catheter Removal Is Accompanied by a Marked Decline in Phlebotomy Blood Loss.Neonatology · 2020Article
- A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions.Nature communications · 2019Article
- To transfuse or not transfuse a premature infant: the new complex question.Journal of perinatology : official journal of the California Perinatal Association · 2019Article
- Epidemiology of Necrotizing Enterocolitis: New Considerations Regarding the Influence of Red Blood Cell Transfusions and Anemia.Clinics in perinatology · 2019Review
- Research Opportunities to Improve Neonatal Red Blood Cell Transfusion.Transfusion medicine reviews · 2016Review
- Reticulocyte Hemoglobin Content During the First Month of Life in Critically Ill Very Low Birth Weight Neonates Differs From Term Infants, Children, and Adults.Journal of clinical laboratory analysis · 2016Article
- Predictive factors and practice trends in red blood cell transfusions for very-low-birth-weight infants.Pediatric research · 2016Article
- Acute drop in blood monocyte count differentiates NEC from other causes of feeding intolerance.Journal of perinatology : official journal of the California Perinatal Association · 2014Article
- Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.Pediatric research · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundVery preterm infants commonly develop anemia requiring multiple red blood cell transfusions (RBCTx). This is in part attributable to heavy laboratory phlebotomy loss. Quantification of the extent to which laboratory blood loss contributes to anemia sufficient to prompt RBCTx has not been examined. STUDY DESIGN AND
methodsTwenty-six preterm infants weighing less than 1500 g at birth requiring ventilator support who received one or more RBCTx were intensively studied during the first month of life. Hemoglobin (Hb) loss via laboratory blood loss and RBC senescence and Hb gain from RBCTx were precisely accounted for in a Hb mass balance mathematical model developed to assess the impact of phlebotomy on RBCTx when restrictive RBCTx criteria were applied.
resultsStudy subjects had a birth weight of 880 ± 240 g (mean ± SD) and a Hb level of 14.4 ± 2.4 g/dL at birth and received 3.81 ± 2.15 RBCTx during the study period. Modeling indicated that even with the total elimination of laboratory phlebotomy loss, a reduction of 41% to 48% in RBCTx was achievable.
conclusionThe present modeling results indicate that while phlebotomy reduction can significantly decrease the number of RBCTx administered to preterm infants, total elimination of all RBCTx will likely require other approaches, for example, stimulation of erythropoiesis with erythropoiesis-stimulating agents.
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