Evidence map›Paper›PMID 23033239›Full record

Trial reportDiabetes care2013

High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D.

Mayer B Davidson, Petra Duran, Martin L Lee, Theodore C Friedman

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02416193 (Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes?), which is not on this map. Cited by 99 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 9 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02416193 phase2terminatednot on this mapstarted 2015, after this paper: background citation

Can Vitamin D3 Improve Cognitive Function in Individuals With Type 2 Diabetes? (THINK-D)

TypeinterventionalSponsorLoyola UniversityRan2015 to 2018Enrolled56ConditionsDiabetes, Executive DysfunctionArmsCholecalciferol
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 9 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  18. EFFECT OF HIGH-DOSE VITAMIN D REPLETION ON GLYCEMIC CONTROL IN AFRICAN-AMERICAN MALES WITH PREDIABETES AND HYPOVITAMINOSIS D.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2015
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mayer B DavidsonDepartment of Internal Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University, Los Angeles, CA, USA. mayerdavidson@cdrewu.edu
Petra Duran
Martin L Lee
Theodore C Friedman
Charles R. Drew University of Medicine and Science · US

Funding

Workshop for Junior Biostatisticians in Health ResearchU54MD007598 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI Jaydutt V. Vadgama · 2012 to 2026
$60.0M
VITAMIN D STIMULATES CARDIAC DIFFERENTIATIONU54RR026138 · NCRR · CHARLES R. DREW UNIVERSITY OF MED & SCI · PI NORRIS, KEITH C · 2009 to 2011
$14.0M
Testosterone Action on Muscle Injury and RepairS06GM068510 · NIGMS · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI SINHA HIKIM, AMIYA P · 2003 to 2010
$5.2M
Drew MIDARP (Infrastructure in Drug Abuse Research)R24DA017298 · NIDA · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI FRIEDMAN, THEODORE C · 2004 to 2018
$5.0M
NCRR NIH HHS U54 RR026138NIDA NIH HHS R24 DA017298NIDA NIH HHS R24DA017298NIGMS NIH HHS S06 GM068510NIGMS NIH HHS S06GM068510NIMHD NIH HHS U54 MD007598NIMHD NIH HHS U54MD007598
6 · The paper itself

Abstract

objectiveLow vitamin D levels predict the development of diabetes. This double-blind, randomized, control study in subjects with prediabetes and hypovitaminosis D evaluated whether high doses of vitamin D for 1 year affected insulin secretion, insulin sensitivity, and the development of diabetes. RESEARCH DESIGN AND

methodsA total of 1,551 subjects ≥40 years of age not known to have diabetes were screened with A1C levels. Subjects with A1C levels of 5.8-6.9% underwent an oral glucose tolerance test (OGTT). Subjects with prediabetes and 25-OH vitamin D (25-OHD) levels <30 ng/mL were randomized to receive weekly placebo (n = 53) or vitamin D (n = 56) with doses based on body weight and baseline 25-OHD levels. OGTTs were performed 3, 6, 9, and 12 months later. Insulin secretion and sensitivity were measured, and the proportion of subjects developing diabetes was assessed.

results25-OHD levels rapidly rose from 22 to nearly 70 ng/mL after vitamin D supplementation with a mean weekly dose of 88,865 IU. There were no differences between the placebo and vitamin D groups regarding fasting plasma glucose, 2-h glucose, or insulin secretion and sensitivity or in the percent developing diabetes or returning to normal glucose tolerance. No subjects experienced increased serum or urinary calcium levels. At 12 months, A1C levels were significantly slightly less (0.2%) in the vitamin D group.

conclusionsIn individuals with prediabetes and hypovitaminosis D, doses of vitamin D supplementation designed to raise serum 25-OHD levels into the upper-normal range for 1 year had no effect on insulin secretion, insulin sensitivity, or the development of diabetes compared with placebo administration.

Indexed as

Dietary SupplementsDouble-Blind MethodFemaleGlucose Tolerance TestGlycated HemoglobinHumansMaleMiddle AgedPrediabetic StateVitamin DGlycated HemoglobinVitamin D

Identifiers

PMID23033239
PMCPMC3554269
OpenAlexW2158741047

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.