ArticleThe Journal of infectious diseases2012
Candida albicans biofilms do not trigger reactive oxygen species and evade neutrophil killing.
Article in The Journal of infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 112 citations in OpenAlex.
- Review
- The PP2A Catalytic Subunit PPH21 Regulates Biofilm Formation and Drug Resistance ofMicroorganisms · 2025Article
- The hypoxic microenvironment ofFrontiers in immunology · 2025Article
- Molecular Determinants Involved in Candida albicans Biofilm Formation and Regulation.Molecular biotechnology · 2024Review
- Analyses of the Chemical Composition of Plasma-Activated Water and Its Potential Applications for Vaginal Health.Biomedicines · 2023Article
- Review
- Interactions between Bacteria andJournal of fungi (Basel, Switzerland) · 2023Review
- Increased Activities against Biofilms of the Pathogenic YeastPharmaceutics · 2022Article
- Development of Antibiofilm Therapeutics Strategies to Overcome Antimicrobial Drug Resistance.Microorganisms · 2022Review
- Growth ofJournal of fungi (Basel, Switzerland) · 2022Review
- The Role of the Oral Immune System in Oropharyngeal Candidiasis-Facilitated Invasion and Dissemination ofFrontiers in oral health · 2022Review
- Reverse effects ofFrontiers in cellular and infection microbiology · 2022Article
- Menthol InhibitsEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Multilocus Sequence Typing and Antifungal Susceptibility ofFrontiers in veterinary science · 2022Article
- Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies.PLoS computational biology · 2021Article
- Review
- Antibiofilm peptides: overcoming biofilm-related treatment failure.RSC advances · 2021Review
- Evaluation of Anti-Biofilm Capability of Cordycepin AgainstInfection and drug resistance · 2021Article
- Automated quantification of Candida albicans biofilm-related phenotypes reveals additive contributions to biofilm production.NPJ biofilms and microbiomes · 2020Article
- Contributions of the Biofilm Matrix toJournal of fungi (Basel, Switzerland) · 2020Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Neutrophils are found within Candida albicans biofilms in vivo and could play a crucial role in clearing the pathogen from biofilms forming on catheters and mucosal surfaces. Our goal was to compare the antimicrobial activity of neutrophils against developing and mature C. albicans biofilms and identify biofilm-specific properties mediating resistance to immune cells. Antibiofilm activity was measured with the 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)2H-tetrazolium-5-carboxanilide assay and a molecular Candida viability assay. Reactive oxygen species generation was assessed by measuring fluorescence of 5-(and-6)-chloromethyl-2',7'-dichlorodihydrofluorescein diacetate, acetyl ester in preloaded neutrophils. We found that mature biofilms were resistant to leukocytic killing and did not trigger reactive oxygen species, even though neutrophils retained their viability and functional activation potential. Beta-glucans found in the extracellular matrix negatively affected antibiofilm activities. We conclude that these polymers act as a decoy mechanism to prevent neutrophil activation and that this represents an important innate immune evasion mechanism of C. albicans biofilms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.