ArticleNature communications2012
Sound-induced length changes in outer hair cell stereocilia.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 38 citations in OpenAlex.
- An artificial cilia-based array system for sound frequency decoding and resonance-responsive drug release.Nature biomedical engineering · 2026Article
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- The sensitivity of mechanoelectrical transduction response phase to acoustic overstimulation is calcium-dependent.Pflugers Archiv : European journal of physiology · 2024Article
- The summating potential polarity encodes the ear health condition.Cellular and molecular life sciences : CMLS · 2023Article
- The morphological and functional diversity of apical microvilli.Journal of anatomy · 2023Review
- Unbalanced bidirectional radial stiffness gradients within the organ of Corti promoted by TRIOBP.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inner hair cell stereocilia are embedded in the tectorial membrane.Nature communications · 2021Article
- Vibration direction sensitivity of the cochlea with bone conduction stimulation in guinea pigs.Scientific reports · 2021Article
- Fluid Jet Stimulation of Auditory Hair Bundles Reveal Spatial Non-uniformities and Two Viscoelastic-Like Mechanisms.Frontiers in cell and developmental biology · 2021Article
- Radixin modulates the function of outer hair cell stereocilia.Communications biology · 2020Article
- Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise.The Journal of the Acoustical Society of America · 2019Review
- Revealing the morphology and function of the cochlea and middle ear with optical coherence tomography.Quantitative imaging in medicine and surgery · 2019Review
- Control of hearing sensitivity by tectorial membrane calcium.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Semicircular canal biomechanics in health and disease.Journal of neurophysiology · 2019Review
- Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.Science advances · 2019Article
- Non-synaptic Plasticity in Leech Touch Cells.Frontiers in physiology · 2019Article
- A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ.Nature communications · 2018Article
- Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae.eLife · 2018Article
- Olivocochlear efferents: Their action, effects, measurement and uses, and the impact of the new conception of cochlear mechanical responses.Hearing research · 2018Review
- Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Hearing relies on mechanical stimulation of stereocilia bundles on the sensory cells of the inner ear. When sound hits the ear, each stereocilium pivots about a neck-like taper near their base. More than three decades of research have established that sideways deflection of stereocilia is essential for converting mechanical stimuli into electrical signals. Here we show that mammalian outer hair cell stereocilia not only move sideways but also change length during sound stimulation. Currents that enter stereocilia through mechanically sensitive ion channels control the magnitude of both length changes and bundle deflections in a reciprocal manner: the smaller the length change, the larger is the bundle deflection. Thus, the transduction current is important for maintaining the resting mechanical properties of stereocilia. Hair cell stimulation is most effective when bundles are in a state that ensures minimal length change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.