Evidence map›Paper›PMID 23032978›Full record

SynthesisThe American journal of gastroenterology2012

Major complications of pneumatic dilation and Heller myotomy for achalasia: single-center experience and systematic review of the literature.

Kristle L Lynch, John E Pandolfino, Colin W Howden, Peter J Kahrilas

Open access · greenAbstract readSystematic Review
In one paragraph

Synthesis in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 4 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 152 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Trial
  7. Endoscopic stent placement for perforation after pneumatic dilation in achalasia.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Outcome of sequential dilatation in achalasia cardia patients: a prospective cohort study.Esophagus : official journal of the Japan Esophageal Society · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Personalized Approach to the Management of Achalasia: How We Do It.The American journal of gastroenterology · 2020
    Article
  20. Esophageal Dysphagia in the Elderly.Current treatment options in gastroenterology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kristle L LynchDepartment of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA.
John E Pandolfino
Colin W Howden
Peter J Kahrilas
Northwestern University · USUniversity Gastroenterology · US

Funding

Multidisciplinary Clinical and Translational Science (MCTS) Program (UL1)UL1TR000150 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LLOYD-JONES, DONALD M · 2012 to 2013
$10.1M
THE ESOPHAGOGASTRIC JUNCTION IN HEALTH AND DISEASER01DK056033 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAHRILAS, PETER JAMES · 2001 to 2015
$4.1M
The mechanics of symptom generation in dysphagiaR01DK079902 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PANDOLFINO, JOHN E · 2009 to 2017
$2.9M
NCATS NIH HHS UL1 TR000150NIDDK NIH HHS R01 DK056033NIDDK NIH HHS R01 DK079902NIDDK NIH HHS R01 DK56033
6 · The paper itself

Abstract

objectivesPneumatic dilation (PD) and laparoscopic Heller myotomy (LHM) can be definitive therapies for achalasia; recent data suggest comparable efficacy. However, risk must also be considered. We reviewed the major complication rate of PD and LHM in a high-volume center and reviewed the corresponding literature.

methodsWe reviewed 12 years of our institution's achalasia treatment experience. During this interval, a consistent technique of PD was used utilizing Rigiflex dilators. Medical records were reviewed for post-procedure complications. We administered a telephone survey and examined medical records to assess efficacy of treatment. We also performed a systematic review of the literature for comparable clinical data and examined 80 reports encompassing 12,494 LHM and PD procedures.

resultsAt our center, 463 achalasia patients underwent 567 PD or LHM procedures. In all, 78% of the PDs used a 30-mm Rigiflex dilator. In all, 157/184 (85%) patients underwent 1 or 2 PD without any subsequent treatment. There were seven clinically significant perforations; one from PD and six from LHM. There were no resultant deaths from these perforations; two deaths occurred within 30 days of LHM from unrelated causes. Complications and deaths post-PD were significantly fewer than those post-LHM (P=0.02).

conclusionsEsophageal perforation from PD at our high-volume center was less common than often reported and lower than that associated with LHM. We conclude that, in the hands of experienced operators using conservative technique, PD has fewer major complications and deaths than LHM.

Indexed as

LaparoscopyAdultAgedDilatationEsophageal AchalasiaEsophageal PerforationEsophagoplastyFemaleHumansMaleMedical RecordsMiddle AgedNorthwestern United StatesRetrospective StudiesSurveys and QuestionnairesTelephone

Identifiers

PMID23032978
PMCPMC3808165
OpenAlexW1981561869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.