ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2012
Longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Body composition after allogeneic haematopoietic cell transplantation/total body irradiation in children and young people: a restricted systematic review.Journal of cancer survivorship : research and practice · 2020Pooled it
- Pre-transplant CRP-albumin ratio as a biomarker in patients receiving haploidentical allogeneic hematopoietic transplantation: Developing a novel DRCI-based nomogram.Frontiers in immunology · 2023Trial
- Telephone-delivered nutrition and exercise counselling after auto-SCT: a pilot, randomised controlled trial.Bone marrow transplantation · 2014Trial
- Prevalence of and Risk Factors for Metabolic Syndrome, Vascular Damage, and Accelerated Aging (MetVasA) After Pediatric Hematopoietic Stem Cell Transplantation for Hematological Malignancy: Protocol for a Cross-Sectional Cohort Study.JMIR research protocols · 2026Article
- Development of A Novel Scoring Index to Quantify the Need for Nutritional Support Interventions During Stem Cell Transplant and Gene Therapy in Children.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Article
- Prevalence and Determinants of Diabetes Mellitus in 2338 Long-Term Dutch Childhood Cancer Survivors (DCCS-LATER2 Study).The Journal of clinical endocrinology and metabolism · 2025Article
- Body Composition Assessment Provides Prognostic Information in Patients With Cancer Affected by Chronic Graft vs. Host Disease.Journal of cachexia, sarcopenia and muscle · 2025Article
- Article
- The evolution and impact of sarcopenia in severe aplastic anaemia survivors following allogeneic haematopoietic cell transplantation.Journal of cachexia, sarcopenia and muscle · 2024Article
- The emerging role of nutritional support in the supportive care of pediatric patients undergoing hematopoietic stem cell transplantation.Frontiers in nutrition · 2023Review
- Patient-reported long-term outcome following allogeneic hematopoietic stem cell transplantation in pediatric chronic myeloid leukemia.Frontiers in oncology · 2022Article
- Weight loss in children undergoing allogeneic hematopoietic stem cell transplantation within the first 100 days: Its influencing factors and impact on clinical outcomes.Frontiers in nutrition · 2022Article
- Altered body composition in male long-term survivors of paediatric allogeneic haematopoietic stem cell transplantation: impact of conditioning regimen, chronic graft-versus-host disease and hypogonadism.Bone marrow transplantation · 2021Article
- Metabolic Syndrome Parameters, Determinants, and Biomarkers in Adult Survivors of Childhood Cancer: Protocol for the Dutch Childhood Cancer Survivor Study on Metabolic Syndrome (Dutch LATER METS).JMIR research protocols · 2021Article
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.Einstein (Sao Paulo, Brazil) · 2021Article
- Total Body Irradiation in Haematopoietic Stem Cell Transplantation for Paediatric Acute Lymphoblastic Leukaemia: Review of the Literature and Future Directions.Frontiers in pediatrics · 2021Review
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Graft- versus -host disease.Einstein (Sao Paulo, Brazil) · 2020Article
- Factors affecting weight and body composition in childhood cancer survivors-cross-sectional study.Ecancermedicalscience · 2020Article
- Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Adults.Einstein (Sao Paulo, Brazil) · 2020Article
- Changes in body composition in children with acute graft-versus-host disease within the first 100 days after hematopoietic stem cell transplantation.European journal of clinical nutrition · 2018Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo measure longitudinal changes in body mass and composition in survivors of childhood hematologic malignancies after allogeneic hematopoietic stem-cell transplantation (HSCT). PATIENTS AND
methodsBody mass index (BMI) was analyzed in 179 survivors by category (underweight, healthy-weight, overweight, and obese) and by z score. Fat and lean body mass measured by dual-energy x-ray absorptiometry was analyzed as z scores.
resultsOver a median 6.6 years of follow-up, BMI z scores diminished significantly (0.32 pre-HSCT v -0.60 at 10 years post-HSCT; P < .001). Mean z scores for fat mass stayed within population norms, but those for lean mass remained below normal levels and diminished significantly over time (P = .018). Pre-HSCT BMI category and/or z score were strongly predictive of post-HSCT BMI (P < .001) and of fat and lean mass z scores (both P < .001). Survivors with extensive chronic graft-versus-host disease were more likely than others to have low BMI (P = .004) and low lean mass (P < .001) post-HSCT. Older age at HSCT (P = .015) and T-cell-depleted graft (P = .018) were predictive of lower post-HSCT BMI. Female patients had higher body fat (P = .002) and lower lean mass (P = .013) z scores than male patients, and black patients had higher fat mass z scores than white patients (P = .026).
conclusionBMI declines significantly after allogeneic HSCT for childhood hematologic malignancies, reflecting primarily a substantial decrease in lean mass but not fat mass. Monitoring and preservation of BMI and lean mass are vital, especially in those with the identified risk factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.