ArticleKidney international2013
Changes in bone structure and the muscle-bone unit in children with chronic kidney disease.
Article in Kidney international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Major contributors to musculoskeletal pain among children receiving hemodialysis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Article
- Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity.Pediatric nephrology (Berlin, Germany) · 2023Article
- Bone accrual and structural changes over one year in youth with cystic fibrosis.Journal of clinical & translational endocrinology · 2022Article
- Muscle-bone axis in children with chronic kidney disease: current knowledge and future perspectives.Pediatric nephrology (Berlin, Germany) · 2021Review
- Deficits in the Functional Muscle-Bone Unit in Youths with Fontan Physiology.The Journal of pediatrics · 2021Article
- A narrative review of skeletal muscle atrophy in critically ill children: pathogenesis and chronic sequelae.Translational pediatrics · 2021Review
- Association between insulin growth factor-1, bone mineral density, and frailty phenotype in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Bone Health in Childhood Chronic Disease.Endocrinology and metabolism clinics of North America · 2020Review
- Poor Glycemic Control Is Associated With Impaired Bone Accrual in the Year Following a Diagnosis of Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2019Article
- Muscle wasting in chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2018Review
- Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism.BMC nephrology · 2018Article
- KNOW-Ped CKD (KoreaN cohort study for outcomes in patients with pediatric CKD): Design and methods.BMC nephrology · 2016Observational
- Micro-CT in the Assessment of Pediatric Renal Osteodystrophy by Bone Histomorphometry.Clinical journal of the American Society of Nephrology : CJASN · 2016Article
- Fracture Burden and Risk Factors in Childhood CKD: Results from the CKiD Cohort Study.Journal of the American Society of Nephrology : JASN · 2016Article
- Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2016Article
- Insulin-like Growth Factor 1 and Adiponectin and Associations with Muscle Deficits, Disease Characteristics, and Treatments in Rheumatoid Arthritis.The Journal of rheumatology · 2015Article
- Structural Bone Deficits in HIV/HCV-Coinfected, HCV-Monoinfected, and HIV-Monoinfected Women.The Journal of infectious diseases · 2015Article
- Deficits in bone density and structure in children and young adults following Fontan palliation.Bone · 2015Article
- Automated Greulich-Pyle bone age determination in children with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The impact of pediatric chronic kidney disease (CKD) on acquisition of volumetric bone mineral density (BMD) and cortical dimensions is lacking. To address this issue, we obtained tibia quantitative computed tomography scans from 103 patients aged 5-21 years with CKD (26 on dialysis) at baseline and 12 months later. Gender, ethnicity, tibia length, and/or age-specific Z-scores were generated for trabecular and cortical BMD, cortical area, periosteal and endosteal circumference, and muscle area based on over 700 reference subjects. Muscle area, cortical area, and periosteal and endosteal Z-scores were significantly lower at baseline compared with the reference cohort. Cortical BMD, cortical area, and periosteal Z-scores all exhibited a significant further decrease over 12 months. Higher parathyroid hormone levels were associated with significantly greater increases in trabecular BMD and decreases in cortical BMD in the younger patients (significant interaction terms for trabecular BMD and cortical BMD). The estimated glomerular filtration rate was not associated with changes in BMD Z-scores independent of parathyroid hormone. Changes in muscle and cortical area were significantly and positively associated in control subjects but not in CKD patients. Thus, children and adolescents with CKD have progressive cortical bone deficits related to secondary hyperparathyroidism and potential impairment of the functional muscle-bone unit. Interventions are needed to enhance bone accrual in childhood-onset CKD.
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