ArticleGenetic epidemiology2013
Genetic association test for multiple traits at gene level.
Article in Genetic epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of quantitative pleiotropic traits for next-generation sequencing with multivariate functional linear models.European journal of human genetics : EJHG · 2017Pooled it
- A copula-based set-variant association test for bivariate continuous, binary or mixed phenotypes.The international journal of biostatistics · 2023Article
- Genetic and Environmental Predictors of Adolescent PTSD Symptom Trajectories Following a Natural Disaster.Brain sciences · 2019Article
- A preliminary investigation of rare variants associated with genetic risk for PTSD in a natural disaster-exposed adolescent sample.European journal of psychotraumatology · 2019Article
- Powerful and robust cross-phenotype association test for case-parent trios.Genetic epidemiology · 2018Article
- A functional U-statistic method for association analysis of sequencing data.Genetic epidemiology · 2017Article
- Genome-wide association test of multiple continuous traits using imputed SNPs.Statistics and its interface · 2017Article
- A method for analyzing multiple continuous phenotypes in rare variant association studies allowing for flexible correlations in variant effects.European journal of human genetics : EJHG · 2016Article
- Quality Control for the Illumina HumanExome BeadChip.Current protocols in human genetics · 2016Article
- Powerful and Adaptive Testing for Multi-trait and Multi-SNP Associations with GWAS and Sequencing Data.Genetics · 2016Article
- Joint analysis of multiple blood pressure phenotypes in GAW19 data by using a multivariate rare-variant association test.BMC proceedings · 2016Article
- Article
- Pleiotropy analysis of quantitative traits at gene level by multivariate functional linear models.Genetic epidemiology · 2015Article
- A genome-wide association study of early spontaneous preterm delivery.Genetic epidemiology · 2015Article
- Association Tests of Multiple Phenotypes: ATeMP.PloS one · 2015Article
- NCK2 is significantly associated with opiates addiction in African-origin men.TheScientificWorldJournal · 2013Article
- A genetic deconstruction of neurocognitive traits in schizophrenia and bipolar disorder.PloS one · 2013Article
- Large scale association analysis for drug addiction: results from SNP to gene.TheScientificWorldJournal · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Genome-wide association studies (GWASs) at the gene level are commonly used to understand biological mechanisms underlying complex diseases. In general, one response or outcome is used to present a disease of interest in such studies. In this study, we consider a multiple traits association test from the gene level. We propose and examine a class of test statistics that summarizes the association information between single nucleotide polymorphisms (SNPs) and each of the traits. Our simulation studies demonstrate the advantage of gene-based multiple traits association tests when multiple traits share common genes. Using our proposed tests, we reanalyze the dataset from the Study of Addiction: Genetics and Environment (SAGE). Our result validates previous findings while presenting stronger evidence for consideration of multiple traits.
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