Evidence map›Paper›PMID 23032305›Full record

Trial reportAppetite2013

The TaqIA RFLP is associated with attenuated intervention-induced body weight loss and increased carbohydrate intake in post-menopausal obese women.

Jameason D Cameron, Marie-Ève Riou, Frédérique Tesson, Gary S Goldfield, Rémi Rabasa-Lhoret, Martin Brochu, Éric Doucet

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Appetite, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Impact of theInternational journal of environmental research and public health · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. DRD2: Bridging the Genome and Ingestive Behavior.Trends in cognitive sciences · 2017
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Jameason D CameronSchool of Human Kinetics, University of Ottawa, Ontario, Canada K1N 6N5.
Marie-Ève RiouSchool of Human Kinetics, University of Ottawa, Ontario, Canada K1N 6N5.
Frédérique TessonInterdisciplinary School of Health Sciences, University of Ottawa, Ontario, Canada.
Gary S GoldfieldSchool of Human Kinetics, University of Ottawa, Ontario, Canada K1N 6N5; Children's Hospital of Eastern Research Institute, Ottawa, Ontario, Canada.
Rémi Rabasa-LhoretDepartment of Nutrition, Université de Montréal, Montréal, Canada; Montreal Institute for Clinical Research (IRCM), Montréal, Canada; Montreal Diabetes Research Center (MDRC) of Centre de Recherche du centre Hospitalier de l'Université de Montréal (CR-CHUM), Montréal, Canada.
Martin BrochuFaculty of Physical Education and Sports, University of Sherbrooke, Sherbrooke, QC, Canada; Research Centre on Aging, Social Services and Health Centre, University Institute of Geriatrics of Sherbrooke, QC, Canada.
Éric DoucetSchool of Human Kinetics, University of Ottawa, Ontario, Canada K1N 6N5. Electronic address: edoucet@uottawa.ca.
University of Ottawa · CAChildren's Hospital of Eastern Ontario · CAHealth and Social Services Centre University Institute of Geriatrics of Sherbrooke · CAMontreal Clinical Research Institute · CA

Funding

CIHR 63279-1
6 · The paper itself

Abstract

introductionPolymorphisms of the dopamine receptor D2 (DRD2) gene have been associated with obesity phenotypes. Our aim was to examine if the genotype of TaqIA Restriction Fragment Length Polymorphism (RFPL) was related to an attenuated weight loss response or to changes in energy expenditure (EE) and food preference before and after weight loss. methods: Obese post-menopausal women (age=57.1 ± 4.6 yr, weight=85.4 ± 15.4 kg and BMI=32.8 ± 4.5 kg/m(2)) were genotyped for TaqIA (n=127) by using PCR-RFLP analysis and categorized as possessing at least one copy of the A1 allele (A1(+)) or no copy (A1(-)). Women were randomized into two groups, caloric restriction (CR) and caloric restriction+resistance training (CRRT) and in this study were further classified as follows: A1(+)CR, A1(+)CRRT, A1-(-)CR and (-)A1(-)CRRT. Body composition, total daily EE, physical activity EE, Resting EE (REE), and energy intake were obtained at baseline and post-intervention using DXA, doubly-labeled water, indirect calorimetry, and 3-day dietary records, respectively.

resultsOverall, all of the anthropometric variables and REE significantly decreased post-intervention (p<0.001). Women in the CRRT group lost significantly more fat mass (FM) than the CR women (p<0.05). There were significant time by group by allele interactions for attenuated body weight (BW), BMI, and FM loss for A1(+) (vs. A1(-)) in CRRT (p<0.05) and for increased % carbohydrate intake (p<0.01).

conclusionTaqIA genotype was associated with body weight loss post-intervention; more specifically, carriers of the A1 allele lost significantly less BW and FM than the A1(-) and had increased carbohydrate intake in the CRRT group.

Indexed as

Caloric RestrictionAbsorptiometry, PhotonAgedAllelesBody CompositionBody Mass IndexCalorimetry, IndirectDietary CarbohydratesEnergy MetabolismFemaleGenotypeHumansMiddle AgedObesityPolymorphism, GeneticPolymorphism, Restriction Fragment LengthDietary Carbohydrates

Identifiers

PMID23032305
PMCPMC3934842
OpenAlexW1999724180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.