ArticleJournal of molecular and cellular cardiology2013
Influence of dark phase restricted high fat feeding on myocardial adaptation in mice.
Article in Journal of molecular and cellular cardiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
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- Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure.Circulation research · 2024Review
- Time-restricted feeding regulates lipid metabolism under metabolic challenges.BioEssays : news and reviews in molecular, cellular and developmental biology · 2023Review
- Cardiomyocyte-specific disruption of the circadian BMAL1-REV-ERBα/β regulatory network impacts distinct miRNA species in the murine heart.Communications biology · 2023Article
- Novel Roles for the Transcriptional Repressor E4BP4 in Both Cardiac Physiology and Pathophysiology.JACC. Basic to translational science · 2023Article
- Finding balance: understanding the energetics of time-restricted feeding in mice.Obesity (Silver Spring, Md.) · 2023Review
- Circadian rhythms in cardiac metabolic flexibility.Chronobiology international · 2023Review
- Review
- Complex physiology and clinical implications of time-restricted eating.Physiological reviews · 2022Review
- [Time-restricted eating as a novel strategy for treatment of obesity and it's comorbid conditions].Problemy endokrinologii · 2022Review
- Acceptability of Time-Limited Eating in Pediatric Weight Management.Frontiers in endocrinology · 2022Article
- Interconnections between circadian clocks and metabolism.The Journal of clinical investigation · 2021Review
- Branched chain amino acids selectively promote cardiac growth at the end of the awake period.Journal of molecular and cellular cardiology · 2021Article
- Impact of obesity on day-night differences in cardiac metabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Nuclear receptor binding factor 2 (NRBF2) is required for learning and memory.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Review
- Differential effects of REV-ERBα/β agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption.American journal of physiology. Heart and circulatory physiology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Prolonged high fat feeding is associated with myocardial contractile dysfunction in rodents. However, epidemiological data do not necessarily support the concept that fat-enriched diets adversely affect cardiac function in humans. When fed in an ad libitum manner, laboratory rodents consume chow throughout the day. In contrast, humans typically consume food only during the awake phase. Discrepancies between rodent and human feeding behaviors led us to hypothesize that the time of day at which dietary lipids are consumed significantly influences myocardial adaptation. In order to better mimic feeding behavior in humans, mice were fed (either a control or high fat diet) only during the 12-hour dark phase (i.e., no food was provided during the light phase). We report that compared to dark phase restricted control diet fed mice, mice fed a high fat diet during the dark phase exhibit: 1) essentially normal body weight gain and energy balance; 2) increased fatty acid oxidation at whole body, as well as skeletal and cardiac muscle (in the presence of insulin and/or at high workloads) levels; 3) induction of fatty acid responsive genes, including genes promoting triglyceride turnover in the heart; 4) no evidence of cardiac hypertrophy; and 5) persistence/improvement of myocardial contractile function, as assessed ex vivo. These data are consistent with the hypothesis that ingestion of dietary fat only during the more active/awake period allows adequate metabolic adaptation, thereby preserving myocardial contractile function. This article is part of a Special Issue entitled "Focus on cardiac metabolism".
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.