Trial reportBMC musculoskeletal disorders2012
The effect of continuous ultrasound on chronic non-specific low back pain: a single blind placebo-controlled randomized trial.
Trial report in BMC musculoskeletal disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03329482 (Effect of Pulse Ultrasound and Kneading Massage Using Lofnac -Gel in the Management of NSCLBP), which is not on this map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Pulse Ultrasound and Kneading Massage Using Lofnac -Gel in the Management of NSCLBP
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Therapeutic ultrasound for chronic low back pain.The Cochrane database of systematic reviews · 2020Pooled it
- Sustained acoustic medicine treatment of discogenic chronic low back pain: A randomized, multisite, double-blind, placebo-controlled trial.Journal of back and musculoskeletal rehabilitation · 2024Trial
- Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial.Journal of pain research · 2020Trial
- Trial
- Effectiveness of ultrasound treatment applied with exercise therapy on patients with ankylosing spondylitis: a double-blind, randomized, placebo-controlled trial.Rheumatology international · 2016Trial
- Comparison of high-intensity laser therapy and ultrasound treatment in the patients with lumbar discopathy.BioMed research international · 2015Trial
- Neurofunctional Changes Following Multimodal Rehabilitation Treatment in Patients with Cervical Spondylosis: An Exploratory Electrophysiological Study.Diagnostics (Basel, Switzerland) · 2026Article
- Neurofunctional Assessments in Lumbar Spondylosis: Outcomes After Rehabilitation Treatment.Journal of functional morphology and kinesiology · 2026Article
- Physical Modalities for the Treatment of Pain in Patients with Fibromyalgia.Mediterranean journal of rheumatology · 2025Review
- Confirmation of the viability of a metaverse yoga class and investigation into the impact on pain, anxiety, and depression associated with low back pain after engaging in virtual yoga sessions.Journal of exercise rehabilitation · 2024Article
- An Updated Overview of Low Back Pain Management.Asian spine journal · 2022Article
- Comparison of the effectiveness of conventional physical therapy and extracorporeal shock wave therapy on pain, disability, functional status, and depression in patients with chronic low back pain.Turkish journal of physical medicine and rehabilitation · 2022Article
- A Comparison of the Effect of a 4.4-MHz Radiofrequency Deep Heating Therapy and Ultrasound on Low Back Pain: A Randomized, Double-Blind, Multicenter Trial.Journal of clinical medicine · 2022Article
- A Review of Laser Therapy and Low-Intensity Ultrasound for Chronic Pain States.Current pain and headache reports · 2022Review
- Low-Intensity Continuous Ultrasound Therapies—A Systematic Review of Current State-of-the-Art and Future Perspectives.Journal of clinical medicine · 2021Review
- Effectiveness of Ultrasound Therapy on the Management of Chronic Non-Specific Low Back Pain: A Systematic Review.Journal of pain research · 2021Review
- Effects of High - Intensity Laser in Treatment of Patients with Chronic Low Back Pain.Open access Macedonian journal of medical sciences · 2019Article
- Effects of pulse ultrasound and kneading massage in managing individual with incessant pain at lower region of back using random allocation.Journal of exercise rehabilitation · 2018Article
- Therapeutic efficacy of Lofnac Gel via phonophoresis in the management of chronic nonspecific low back pain: A randomised controlled trial.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2015Article
- Management options for patients with chronic back pain without an etiology.Health services insights · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-specific chronic low back pain (NSCLBP) is one of the most common musculoskeletal disorders around the world including Iran. One of the most widely used modalities in the field of physiotherapy is therapeutic ultrasound (US). Despite its common use, there is still inconclusive evidence to support its effectiveness in patients with NSCLBP. The objective of this study was to evaluate the effect of continuous US compared with placebo US additional to exercise therapy for patients with NSCLBP.
methodsIn this single blind placebo controlled study, 50 patients with NSCLBP were randomized into two treatment groups: 1) continuous US (1 MHz &1.5 W/cm2) plus exercise 2) placebo US plus exercise. Patients received treatments for 4 weeks, 10 treatment sessions, 3 times per week, every other day. Treatment effects were assessed in terms of primary outcome measures: 1) functional disability, measured by Functional Rating Index, and 2) global pain, measured by a visual analog scale. Secondary outcome measures were lumbar flexion and extension range of motion (ROM), endurance time and rate of decline in median frequency of electromyography spectrum during a Biering Sorensen test. All outcome variables were measured before, after treatment, and after one-month follow-up. An intention to treat analysis was performed. Main effects of Time and Group as well as their interaction effect on outcome measures were investigated using repeated measure ANOVA.
resultsAnalysis showed that both groups had improved regarding function (FRI) and global pain (VAS) (P < .001). Lumbar ROM as well as holding time during the Sorensen test and median frequency slope of all measured paravertebral muscles did not change significantly in either group (P > .05). Improvement in function and lumbar ROM as well as endurance time were significantly greater in the group receiving continuous US (P < .05).
conclusionsThe study showed that adding continuous US to a semi supervised exercise program significantly improved function, lumbar ROM and endurance time. Further studies including a third group of only exercise and no US can establish the possible effects of placebo US.
trial registrationNTR2251.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.