ArticleBMC neurology2012
Risk factors for ischemic stroke; results from 9 years of follow-up in a population based cohort of Iran.
Article in BMC neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Zinc deficiency in patients with type 2 diabetes increases risk of cardiovascular diseases: Tehran Lipid and Glucose Study.BMC cardiovascular disorders · 2026Article
- Sex-Specific Prospective Association of Serum Zinc Concentration with Cardiovascular Disease and Mortality: A 10-Year Population-Based Cohort Study.Journal of cardiovascular translational research · 2026Article
- In-hospital mortality and its predictors among adult ischemic stroke patients in public hospitals in the Harari region, Eastern Ethiopia: A retrospective cohort study.Journal of public health research · 2026Article
- Cardiovascular disease risk prediction by Framingham risk score in women with polycystic ovary syndrome.Reproductive biology and endocrinology : RB&E · 2025Article
- Association of classic cardiovascular risk factors with myocardial infarction and ischemic stroke: A cross sectional analysis of the Shiraz Heart Study.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- The difference between 2-hour post-challenge and fasting plasma glucose associates with the risk of cardiovascular disease in a normoglycemic population: the Tehran lipid and glucose study.Nutrition & metabolism · 2024Article
- The association between metabolic syndrome and insulin resistance with risk of cardiovascular events in different states of cardiovascular health status.Journal of diabetes investigation · 2024Article
- Effects of the liaison nurse management on the infectious stroke complications: a randomized controlled trial.BMC nursing · 2022Article
- Ideal cardiovascular health status and risk of cardiovascular disease and all-cause mortality: over a decade of follow-up in the Tehran lipid and glucose study.Frontiers in cardiovascular medicine · 2022Article
- Risk profile, clinical presentation, and determinants of stroke subtypes among patients with stroke admitted to public referral hospitals, Northwest Ethiopia in 2021: A cross-sectional study.Frontiers in neurology · 2022Article
- A genetic variant in the promoter of lncRNA MALAT1 is related to susceptibility of ischemic stroke.Lipids in health and disease · 2020Article
- Article
- Diabetes Mellitus: Findings from 20 Years of the Tehran Lipid and Glucose Study.International journal of endocrinology and metabolism · 2018Review
- Tobacco Smoking: Findings from 20 Years of the Tehran Lipid and Glucose Study.International journal of endocrinology and metabolism · 2018Review
- Legacy of the Tehran Lipid and Glucose Study: Chronic Kidney Disease.International journal of endocrinology and metabolism · 2018Review
- Blood Pressure and Hypertension: Findings from 20 Years of the Tehran Lipid and Glucose Study (TLGS).International journal of endocrinology and metabolism · 2018Review
- Prevalence of Stroke Risk Factors and Their Distribution Based on Stroke Subtypes in Gorgan: A Retrospective Hospital-Based Study-2015-2016.Neurology research international · 2018Article
- A population-based national estimate of the prevalence and risk factors associated with hypertension in Rwanda: implications for prevention and control.BMC public health · 2017Article
- Awareness toward stroke in a population-based sample of Iranian adults.Iranian journal of neurology · 2017Article
- Stroke mimics in patients with clinical signs of stroke.Caspian journal of internal medicine · 2017Article
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Authors and funding
5 authors.
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Abstract
backgroundData about the risk factors of stroke are sparse in the Middle East populations. We aimed to determine the potential risk factors and their population attributable fraction (PAF) for stroke in an Iranian population.
methodsA cohort Study consisted of 1089 men and 1289 women, with mean (SD) ages of 61.1(7.6) and 59.0(6.7) years, respectively. Cox regression was implemented to estimate the hazard ratio (HR) of each risk factor for stroke events in a stepwise method. We calculated a multivariate adjusted population attributable fraction (PAF) for any risk factors remained in the model.
resultsDuring 9.3 years of follow-up, 69 events of stroke occurred with incidence rates of 4.5 (95% CI: 3.3-6.0) and 2.5 (1.7-3.6) in 1000 person-years for men and women respectively. Among potential risk factors, only age ≥ 65 years (HR: 2.03, CI: 1.24-3.31), male gender (HR: 2.00, CI: 1.16-3.43), hypertension (HR: 3.03, CI: 1.76-5.22), diabetes mellitus (HR: 2.18, CI: 1.34-3.56), and chronic kidney disease (CKD) (HR: 2.01, CI: 1.22-3.33), were independently associated with increased risk of stroke events in the total population. A paired homogeneity test showed that the hazard ratio of CKD did not differ from other independent risk factors. The PAFs were 29.7% and 25% for male gender and age ≥ 65 as non-modifiable and 48.6%, 29.1% and 22.0% for hypertension, CKD and diabetes as modifiable risk factors respectively.
conclusionFollowing this population based study of Iranians, we demonstrated that among modifiable risk factors, CKD as well as hypertension and diabetes are the strongest independent predictors of stroke.
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