ArticleScandinavian journal of trauma, resuscitation and emergency medicine2012
Early insulin resistance in severe trauma without head injury as outcome predictor? A prospective, monocentric pilot study.
Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Hallmarks of the multidimensional immune response to trauma in humans.Nature immunology · 2026Review
- Insulin Resistance and Homeostatic Model Assessment in Critically Ill: Where do We Stand?Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Severe hyperglycemia and insulin resistance in patients with SARS-CoV-2 infection: a report of two cases.Clinical diabetes and endocrinology · 2021Article
- The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress Syndrome.Diabetes research and clinical practice · 2021Article
- Association of Stress-Induced Hyperglycemia and Diabetic Hyperglycemia with Mortality in Patients with Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population.International journal of environmental research and public health · 2020Article
- Stress Hyperglycemia and Complications Following Traumatic Injuries in Individuals With/Without Diabetes: The Case of Orthopedic Surgery.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Stress-Induced Hyperglycemia, but Not Diabetic Hyperglycemia, Is Associated with Higher Mortality in Patients with Isolated Moderate and Severe Traumatic Brain Injury: Analysis of a Propensity Score-Matched Population.International journal of environmental research and public health · 2017Article
- Plasma First Resuscitation Reduces Lactate Acidosis, Enhances Redox Homeostasis, Amino Acid and Purine Catabolism in a Rat Model of Profound Hemorrhagic Shock.Shock (Augusta, Ga.) · 2016Article
- Association between Hyperglycaemia with Neurological Outcomes Following Severe Head Trauma.Journal of clinical and diagnostic research : JCDR · 2016Article
- Stress-induced hyperglycemia after hip fracture and the increased risk of acute myocardial infarction in nondiabetic patients.Diabetes care · 2013Article
- Mitochondrial dysfunction induces formation of lipid droplets as a generalized response to stress.Oxidative medicine and cellular longevity · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHyperglycemia following major trauma is a well know phenomenon related to stress-induced systemic reaction. Reports on glucose level management in patients with head trauma have been published, but the development of insulin resistance in trauma patients without head injury has not been extensively studied. The aim of this study was therefore to investigate the prognostic role of acute insulin-resistance, assessed by the HOMA model, in patients with severe trauma without head injury.
methodsAll patients consecutively admitted to the Intensive Care Unit (ICU) of a tertiary referral center (Careggi Teaching Hospital, Florence, IT) for major trauma without head injury (Jan-Dec 2010) were enrolled. Patients with a previous diagnosis of diabetes mellitus requiring insulin therapy or metabolism alteration were excluded from the analysis. Patients were divided into "insulin resistant" and "non-insulin resistant" based on the Homeostasis Model Assessment index (HOMA IR). Results are expressed as medians.
resultsOut of 175 trauma patients admitted to the ICU during the study period, a total of 54 patients without head trauma were considered for the study, 37 of whom met the inclusion criteria. In total, 23 patients (62.2%) resulted insulin resistant, whereas 14 patients (37.8%) were non-insulin resistant. Groups were comparable in demographic, clinical/laboratory characteristics, and severity of injury. Insulin resistant patients had a significantly higher BMI (P=0.0416), C-reactive protein (P=0.0265), and leukocytes count (0.0301), compared to non-insulin resistant patients. Also ICU length of stay was longer in insulin resistant patients (P=0.0381).
conclusionsOur data suggest that admission insulin resistance might be used as an early outcome predictor.
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