Trial reportTwin research and human genetics : the official journal of the International Society for Twin Studies2012
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.
Trial report in Twin research and human genetics : the official journal of the International Society for Twin Studies, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.Nature human behaviour · 2025Pooled it
- Twenty-Five Novel Loci for Carotid Intima-Media Thickness: A Genome-Wide Association Study in >45 000 Individuals and Meta-Analysis of >100 000 Individuals.Arteriosclerosis, thrombosis, and vascular biology · 2022Pooled it
- Determination of Zygosity in Adult Chinese Twins Using the 450K Methylation Array versus Questionnaire Data.PloS one · 2015Trial
- Genetic impacts on within-pair DNA methylation variance in monozygotic twins capture gene-environment interactions and cell-type effects.Genome biology · 2026Article
- A Nutrigenetic Update on CETP Gene-Diet Interactions on Lipid-Related Outcomes.Current atherosclerosis reports · 2022Review
- The Danish Twin Registry: An Updated Overview.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019Article
- Heritability and Genome-Wide Association Study of Plasma Cholesterol in Chinese Adult Twins.Frontiers in endocrinology · 2018Article
- Association ofInternational journal of clinical and experimental pathology · 2018Article
- The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits.Scientific reports · 2017Article
- Article
- Association of common variants in TOMM40/APOE/APOC1 region with human longevity in a Chinese population.Journal of human genetics · 2016Article
- Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits.Scientific reports · 2016Article
- A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders.Psychotherapy and psychosomatics · 2016Article
- Gene-Environment Interplay in Physical, Psychological, and Cognitive Domains in Mid to Late Adulthood: Is APOE a Variability Gene?Behavior genetics · 2016Article
- Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins.Nature genetics · 2015Article
- IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.Human molecular genetics · 2014Article
- Genome-wide family-based linkage analysis of exome chip variants and cardiometabolic risk.Genetic epidemiology · 2014Article
- Genetic determinants influencing human serum metabolome among African Americans.PLoS genetics · 2014Article
- THOC5: a novel gene involved in HDL-cholesterol metabolism.Journal of lipid research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 13 institutions in 8 countries.
Funding
Abstract
Genome-wide association analysis on monozygotic twin-pairs offers a route to discovery of gene environment interactions through testing for variability loci associated with sensitivity to individual environment/lifestyle. We present a genome-wide scan of loci associated with intra-pair differences in serum lipid and apolipoprotein levels. We report data for 1,720 monozygotic female twin-pairs from GenomEUtwin project with 2.5 million SNPs, imputed or genotyped, and measured serum lipid fractions for both twins. We found one locus associated with intra-pair differences in high-density lipoprotein cholesterol, rs2483058 in an intron of SRGAP2, where twins carrying the C allele are more sensitive to environmental factors(P=3.98 x 10-8). We followed up the association in further genotyped monozygotic twins (N= 1,261),which showed a moderate association for the variant (P= 0.200, same direction of an effect). In addition,we report a new association on the level of apolipoprotein A-ll (P= 4.03 x 1 o-8).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.