Evidence map›Paper›PMID 2303130›Full record

ArticleExperientia1990

The effect of moderate hemodilution with fluosol-DA or normal saline on acetaminophen disposition in the rat.

R P Shrewsbury, L G White

Abstract read
PubMed Publisher
In one paragraph

Article in Experientia, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R P ShrewsburyDivision of Pharmaceutics, School of Pharmacy, University of North Carolina, Chapel Hill 27599-7360.
L G White
University of North Carolina at Chapel Hill · US

Funding

EFFECT OF PERFLUOROCHEMICAL EXCHANGE ON DRUG KINETICSR01HL033227 · NHLBI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI SHREWSBURY, ROBERT P · 1985 to 1987
–
NHLBI NIH HHS HL 33227
6 · The paper itself

Abstract

Hemodilution with 40 ml/kg of Fluosol or saline reduced the acetaminophen Vd and the acetaminophen sulfate ClM at 48 or 72 h, respectively. Fluosol hemodilution increased the acetaminophen renal excretion at 24 and 72 h. But at 48 h, Fluosol hemodilution either inhibited the renal secretion of acetaminophen or enhanced its reabsorption.

Indexed as

FluorocarbonsHemodilutionPlasma SubstitutesSodium ChlorideAcetaminophenAnimalsCytochrome P-450 Enzyme SystemDrug CombinationsHydroxyethyl Starch DerivativesKidneyMaleRatsRats, Inbred StrainsAcetaminophenCytochrome P-450 Enzyme SystemDrug CombinationsFluorocarbonsglucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combinationHydroxyethyl Starch DerivativesPlasma SubstitutesSodium Chloride

Identifiers

PMID2303130
OpenAlexW2050739606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.