ArticlePhysical review. E, Statistical, nonlinear, and soft matter physics2012
Mathematical modeling of genome replication.
Article in Physical review. E, Statistical, nonlinear, and soft matter physics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- RepliSage: a stochastic graph-based framework for 3D chromatin modeling across the cell cycle.Nucleic acids research · 2026Article
- Regulation of replication timing in Saccharomyces cerevisiae.PLoS computational biology · 2025Article
- DNA replication timing reveals genome-wide features of transcription and fragility.Nature communications · 2025Article
- Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in Xenopus.Nucleic acids research · 2025Article
- Modeling the Dynamics of Eukaryotic DNA Synthesis in Remembrance of Tunde Ogunnaike.Industrial & engineering chemistry research · 2023Article
- Article
- Stochasticity of replication forks' speeds plays a key role in the dynamics of DNA replication.PLoS computational biology · 2019Article
- Molecular Mechanisms of DNA Replication and Repair Machinery: Insights from Microscopic Simulations.Advanced theory and simulations · 2019Article
- Bayesian inference of origin firing time distributions, origin interference and licencing probabilities from Next Generation Sequencing data.Nucleic acids research · 2019Article
- Rapid high-resolution measurement of DNA replication timing by droplet digital PCR.Nucleic acids research · 2018Article
- Article
- Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics.Nucleic acids research · 2017Article
- Model-based analysis of DNA replication profiles: predicting replication fork velocity and initiation rate by profiling free-cycling cells.Genome research · 2017Article
- Mapping ribonucleotides in genomic DNA and exploring replication dynamics by polymerase usage sequencing (Pu-seq).Nature protocols · 2015Article
- A global profile of replicative polymerase usage.Nature structural & molecular biology · 2015Article
- The dynamics of genome replication using deep sequencing.Nucleic acids research · 2014Article
- High-resolution replication profiles define the stochastic nature of genome replication initiation and termination.Cell reports · 2013Article
- Stochastic association of neighboring replicons creates replication factories in budding yeast.The Journal of cell biology · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Eukaryotic DNA replication is initiated from multiple sites on the chromosome, but little is known about the global and local regulation of replication. We present a mathematical model for the spatial dynamics of DNA replication, which offers insight into the kinetics of replication in different types of organisms. Most biological experiments involve average quantities over large cell populations (typically >10(7) cells) and therefore can mask the cell-to-cell variability present in the system. Although the model is formulated in terms of a population of cells, using mathematical analysis we show that one can obtain signatures of stochasticity in individual cells from averaged quantities. This work generalizes the result by Retkute et al. [Phys. Rev. Lett. 107, 068103 (2011)] to a broader set of parameter regimes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.