ArticleFuture oncology (London, England)2012
Significance of clustered tumor suppressor genes in cancer.
Article in Future oncology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- MGMT-Methylated Alleles Are Distributed Heterogeneously Within Glioma Samples Irrespective of IDH Status and Chromosome 10q Deletion.Journal of neuropathology and experimental neurology · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The two-hit model is a well-known mechanism for the inactivation of tumor suppressor genes in cancer and it has been assumed that chromosomal deletions are the second inactivating event. Large deletions are frequently found in cancer and can lead to the haploinsufficiency of the loci mapped to the deleted region. The study by Xue et al. demonstrated that hemizygous 8p deletions can attenuate the activity of multiple genes that control growth and promote tumorigenesis, and showed that the effect of large 8p deletions on tumor phenotype goes beyond the effects of the individual genes as the characteristics of a tumor are also influenced by the additive and/or combined effect of the haploinsufficiency of multiple genes. These convincing findings, demonstrating that the hemizygosity of a cluster of genes negatively regulates proliferation and promotes tumor growth, have opened up new study perspectives aimed at characterizing the genomic organization of this new class of tumor suppressor genes and their role in tumorigenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.