ArticleThe EMBO journal1990
hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
60 citing papers in PubMed, 218 citations in OpenAlex.
- Article
- The Forms of the Lectin Tff2 Differ in the Murine Stomach and Pancreas: Indications for Different Molecular Functions.International journal of molecular sciences · 2023Article
- Different Forms of TFF2, A Lectin of the Human Gastric Mucus Barrier:International journal of molecular sciences · 2019Article
- Probiotics Upregulate Trefoil Factors and Downregulate Pepsinogen in the Mouse Stomach.International journal of molecular sciences · 2019Article
- Early administration of dapagliflozin preserves pancreatic β-cell mass through a legacy effect in a mouse model of type 2 diabetes.Journal of diabetes investigation · 2019Article
- Effect of Initial Periodontal Therapy on Salivary Trefoil Factor (TFF3) in otherwise Healthy Patients with Gingivitis and Chronic Periodontitis.Contemporary clinical dentistry · 2018Article
- Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.Scientific reports · 2017Article
- Production of Monoclonal Antibodies against Human Trefoil Factor 3 and Development of a Modified-Sandwich ELISA for Detection of Trefoil Factor 3 Homodimer in Saliva.Biological procedures online · 2017Article
- Anti-tumor efficacy evaluation of a novel monoclonal antibody targeting neutral amino acid transporter ASCT2 using patient-derived xenograft mouse models of gastric cancer.American journal of translational research · 2017Article
- Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.The Journal of biological chemistry · 2014Article
- Trefoil factors in inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Article
- Investigation of trefoil factor expression in saliva and oral mucosal tissues of patients with oral squamous cell carcinoma.Clinical oral investigations · 2012Article
- Pathophysiological investigation of the gastric surface mucous gel layer of patients with Helicobacter pylori infection by using immunoassays for trefoil factor family 2 and gastric gland mucous cell-type mucin in gastric juice.Digestive diseases and sciences · 2011Article
- The role of trefoil factor family in apparently healthy subjects administrated gastroprotective agents for the primary prevention of gastrointestinal injuries from low-dose acetylsalicylic acid: a preliminary study.Journal of clinical biochemistry and nutrition · 2011Article
- In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.Gut · 2010Article
- A novel non-lens betagamma-crystallin and trefoil factor complex from amphibian skin and its functional implications.PloS one · 2008Article
- Quantitative analysis of the effect of Helicobacter pylori on the expressions of SOX2, CDX2, MUC2, MUC5AC, MUC6, TFF1, TFF2, and TFF3 mRNAs in human gastric carcinoma cells.Scandinavian journal of gastroenterology · 2008Article
- Co-localization of TFF2 with gland mucous cell mucin in gastric mucous cells and in extracellular mucous gel adherent to normal and damaged gastric mucosa.Histochemistry and cell biology · 2006Article
- Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Approximately 50% of human breast tumors secrete a small cysteine-rich protein, pS2, of unknown function. pS2 protein was recently found to be homologous to a porcine protein with hormonogastric activity, pancreatic spasmolytic polypeptide (PSP), in which the 5-cysteine domain present in pS2 is tandemly duplicated. We have characterized cDNA species encoding PSP and its human and mouse counterparts, hSP and mSP. We show that hSP and pS2 are separately encoded in the genome, and that the two proteins are co-expressed in normal stomach epithelium. However, expression of hSP was not detected in breast tumors. Computer analysis revealed that the pattern of conserved cysteine residues in hSP and pS2, the P domain, is present at the N termini of two other mammalian proteins, intestinal sucrase-isomaltase and lysosomal alpha-glucosidase.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.